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Introduction - Basic & Clinical Pharmacology
The History of Pharmacologyogy
Pharmacology & Genetics
Pharmacology and the Pharmaceutical Industry
The Nature of Drugs
Drug-Body Interactions
Pharmacodynamic Principles
Pharmacokinetic Principles
Drug Groups

Drug Receptors Pharmacodynamics

Drug Receptors & Pharmacodynamics
Macromolecular Nature of Drug Receptors
Relation Between Drug Concentration & Response
Signaling Mechanisms & Drug Action
Intracellular Receptors for Lipid-Soluble Agents
Ligand-Regulated Transmembrane Enzymes Including Receptor Tyrosine Kinases
Cytokine Receptors
Ligand- and Voltage-Gated Channels
G Proteins & Second Messengers
Receptor Regulation
Well-Established Second Messengers
Interplay among Signaling Mechanisms
Phosphorylation: A Common Theme
Receptor Classes & Drug Development
Relation Between Drug Dose & Clinical Response
Dose & Response in Patients
Variation in Drug Responsiveness
Clinical Selectivity: Beneficial versus Toxic Effects of Drugs

Pharmacokinetics Pharmacodynamics Rational Dosing the Time Course of Drug Action

Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action
Volume of Distribution - Pharmacokinetics
Clearance - Pharmacokinetics
Half-Life - Pharmacokinetics
Drug Accumulation - Pharmacokinetics
Bioavailability - Pharmacokinetics
The Time Course of Drug Effect
The Target Concentration Approach to Designing a Rational Dosage Regimen
Target Concentration Intervention: Application of Pharmacokinetics & Pharmacodynamics to Dose Individualization
Interpretation of Drug Concentration Measurements

Drug Biotransformation

Drug Biotransformation
Why is Drug Biotransformation Necessary?
The Role of Biotransformation In Drug Disposition
Where Do Drug Biotransformations Occur?
Microsomal Mixed Function Oxidase System & Phase I Reactions
Human Liver P450 Enzymes
Phase II Reactions
Metabolism of Drugs to Toxic Products
Clinical Relevance of Drug Metabolism

Development Regulation of Drugs

Development & Regulation of Drugs
The Pharmaceutical Industry
Drug Discovery
Preclinical Safety & Toxicity Testing
Evaluation in Humans
Confounding Factors in Clinical Trials
The Food & Drug Administration - Evaluation in Humans
Clinical Trials: The IND & NDA - Evaluation in Humans
Conflicts of Interest, Adverse Drug Reactions - Evaluation in Humans
Orphan Drugs & Treatment of Rare Diseases - Evaluation in Humans

Introduction to Autonomic Pharmacology

Introduction to Autonomic Pharmacology
Anatomy of the Autonomic Nervous System
Neurotransmitter Chemistry of the Autonomic Nervous System
Autonomic Receptors
Nonadrenergic, Noncholinergic (NANC) Neurons
Functional Organization of Autonomic Activity
Pharmacologic Modification of Autonomic Function

Cholinoceptor Activating Cholinesterase Inhibiting Drugs

Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs
Spectrum of Action of Cholinomimetic Drugs
Mode of Action of Cholinomimetic Drugs
Basic Pharmacology of the Direct Acting Cholinoceptor Stimulants
Basic Pharmacology of the Indirect Acting Cholinomimetics
Clinical Pharmacology of the Cholinomimetics

Cholinoceptor Blocking Drugs

Cholinoceptor Blocking Drugs
Basic Pharmacology of the Muscarinic Receptor Blocking Drugs
Clinical Pharmacology of the Muscarinic Receptor Blocking Drugs
Basic & Clinical Pharmacology of the Ganglion Blocking Drugs

Adrenoceptor Agonists Sympathomimetic Drugs

Adrenoceptor Agonists & Sympathomimetic Drugs
Molecular Pharmacology Underlying the Actions of Sympathomimetic Drugs
Medicinal Chemistry of Sympathomimetic Drugs
Cardiovascular System - Organ System Effects of Sympathomimetic Drugs
Noncardiac Effects of Sympathomimetics - Organ System Effects of Sympathomimetic Drugs
Endogenous Catecholamines
Direct-Acting Sympathomimetics
Mixed-Acting Sympathomimetics
Indirect-Acting Sympathomimetics
Therapeutic Uses of Sympathomimetic Drugs

Adrenoceptor Antagonist Drugs

Adrenoceptor Antagonist Drugs
Basic Pharmacology of the Alpha Receptor Antagonist Drugs
Specific Agents
Other Alpha-Adrenoceptor Antagonists
Clinical Pharmacology of the Alpha Receptor Blocking Drugs
Basic Pharmacology of the Beta Receptor Antagonist Drugs
Pharmacokinetic Properties of the Beta-Receptor Antagonists
Pharmacodynamics of the Beta-Receptor Antagonist Drugs
Specific Agents
Clinical Pharmacology of the Beta Receptor Blocking Drugs
Choice of a Beta-Adrenoceptor Antagonist Drug
Clinical Toxicity Of The Beta-Receptor Antagonist Drugs

Antihypertensive Agents

Antihypertensive Agents
Hypertension & Regulation of Blood Pressure
Basic Pharmacology of Antihypertensive Agents
Drugs that Alter Sodium & Water Balance
Drugs That Alter Sympathetic Nervous System Function
Centrally Acting Sympathoplegic Drugs
Ganglion-Blocking Agents
Adrenergic Neuron-Blocking Agents
Beta-Adrenoceptor-Blocking Agents
Prazosin & Other Alpha1 Blockers
Sodium Nitroprusside
Calcium Channel Blockers
Inhibitors of Angiotensin
Angiotensin-Converting Enzyme (ACE) Inhibitors
Angiotensin Receptor-Blocking Agents
Clinical Pharmacology of Antihypertensive Agents
Outpatient Therapy of Hypertension
Management of Hypertensive Emergencies

Vasodilators the Treatment of Angina Pectoris

Vasodilators & the Treatment of Angina Pectoris
Pathophysiology of Angina
Basic Pharmacology of Drugs Used to Treat Angina
Nitrates & Nitrites
Drugs Used in the Treatment of Erectile Dysfunction
Calcium Channel-Blocking Drugs
Beta-Blocking Drugs
Newer Antianginal Drugs
Clinical Pharmacology of Drugs Used to Treat Angina
Treatment of Peripheral Artery Disease (PAD) & Intermittent Claudication

Drugs Used in Heart Failure

Drugs Used in Heart Failure
Control of Normal Cardiac Contractility
Pathophysiology of Heart Failure
Pathophysiology of Cardiac Performance
Other Positive Inotropic Drugs Used in Heart Failure
Beta-Adrenoceptor Agonists
Basic Pharmacology of Drugs Used in Heart Failure
Drugs Without Positive Inotropic Effects Used in Heart Failure
Clinical Pharmacology of Drugs Used in Heart Failure
Management of Chronic Heart Failure
Management of Diastolic Heart Failure
Management of Acute Heart Failure

Agents Used in Cardiac Arrhythmias

Agents Used in Cardiac Arrhythmias
Electrophysiology of Normal Cardiac Rhythm
Mechanisms of Arrhythmias
Basic Pharmacology of the Antiarrhythmic Agents
Specific Antiarrhythmic Agents
Procainamide (Subgroup 1A)
Quinidine (SubGroup 1A)
Disopyramide (SubGroup 1A)
Lidocaine (SubGroup 1B)
Mexiletine (SubGroup 1B)
Flecainide (Subgroup 1C)
Propafenone (Subgroup 1C)
Moricizine (Subgroup 1C)
Beta-Adrenoceptor–Blocking Drugs (Class 2)
Drugs That Prolong Effective Refractory Period by Prolonging the Action Potential (Class 3)
Calcium Channel-Blocking Drugs (Class 4)
Adenosine - Antiarrhythmic Agents
Magnesium - Antiarrhythmic Agents
Potassium - Antiarrhythmic Agents
Principles in the Clinical Use of Antiarrhythmic Agents

Diuretic Agents

Diuretic Agents
Proximal Tubule - Renal Tubule Transport Mechanisms
Loop of Henle - Renal Tubule Transport Mechanisms
Distal Convoluted Tubule - Renal Tubule Transport Mechanisms
Collecting Tubule System - Renal Tubule Transport Mechanisms
Renal Autacoids - Renal Tubule Transport Mechanisms
Carbonic Anhydrase Inhibitors
Adenosine A1-Receptor Antagonists
Loop Diuretics
Potassium-Sparing Diuretics
Agents That Alter Water Excretion (Aquaretics)
Diuretic Combinations
Edematous States
Nonedematous States

Histamine Serotonin the Ergot Alkaloids

Basic Pharmacology of Histamine
Clinical Pharmacology of Histamine
Histamine Antagonists
Histamine Receptor Antagonists
Basic Pharmacology of H1-Receptor Antagonists
Clinical Pharmacology of H1-Receptor Antagonists
H2-Receptor Antagonists
H3- & H4-Receptor Antagonists
Serotonin 5 Hydroxytryptamine
Basic Pharmacology of Serotonin
Melatonin Pharmacology
Serotonin Syndrome and Similar Syndromes
Clinical Pharmacology of Serotonin
Serotonin Antagonists
Serotonin-Receptor Antagonists
The Ergot Alkaloids
Basic Pharmacology of Ergot Alkaloids
Clinical Pharmacology of Ergot Alkaloids

Vasoactive Peptides

Vasoactive Peptides
Biosynthesis of Angiotensin
Actions of Angiotensin II
Angiotensin Receptors & Mechanism of Action
Biosynthesis of Kinins
Inhibition of the Renin-Angiotensin System
Formation of Kinins in Plasma & Tissues
Physiologic & Pathologic Effects of Kinins
Kinin Receptors & Mechanisms of Action
Metabolism of Kinins
Drugs Affecting the Kallikrein-Kinin System
Vasopressin Receptors & Antagonists
Natriuretic Peptides
Vasopeptidase Inhibitors
Inhibitors of Endothelin Synthesis & Action
Vasoactive Intestinal Peptide
Substance P
Calcitonin Gene Related Peptide
Neuropeptide Y

The EicosanoidsProstaglandins Thromboxanes Leukotrienes Related Compounds

Arachidonic Acid & Other Polyunsaturated Precursors
Synthesis of Eicosanoids
Receptor Mechanisms - Mechanisms & Effects of Eicosanoids
Effects of Prostaglandins & Thromboxanes
Effects of Lipoxygenase & Cytochrome P450-Derived Metabolites
Inhibition of Eicosanoid Synthesis
Clinical Pharmacology of Eicosanoids
Dietary Manipulation of Arachidonic Acid Metabolism

Nitric Oxide

Discovery of Endogenously Generated Nitric Oxide
Nitric Oxide Synthesis, Signaling Mechanisms, & Inactivation
Pharmacologic Manipulation of Nitric Oxide
Vascular Effects - Nitric Oxide in Disease
Septic Shock - Nitric Oxide in Disease
Infection & Inflammation - Nitric Oxide in Disease
The Central Nervous System - Nitric Oxide in Disease
The Peripheral Nervous System - Nitric Oxide in Disease
Respiratory Disorders - Nitric Oxide in Disease

Drugs Used in Asthma

Drugs Used in Asthma
Pathogenesis of Asthma
Sympathomimetic Agents - Basic Pharmacology of Agents Used in the Treatment of Asthma
Methylxanthine Drugs - Basic Pharmacology of Agents Used in the Treatment of Asthma
Antimuscarinic Agents - Basic Pharmacology of Agents Used in the Treatment of Asthma
Corticosteroids - Basic Pharmacology of Agents Used in the Treatment of Asthma
Leukotriene Pathway Inhibitors - Basic Pharmacology of Agents Used in the Treatment of Asthma
Anti-IgE Monoclonal Antibodies - Drugs in the Treatment of Asthma
Cromolyn & Nedocromil
Clinical Pharmacology of Drugs Used In the Treatment of Asthma
Muscarinic Antagonists
Leukotriene Antagonists; Cromolyn & Nedocromil
Anti-Ige Monoclonal Antibody
Management of Acute Asthma
Prospects for Prevention of Asthma
Treatment Of Chronic Obstructive Pulmonary Disease (COPD)


Introduction to the Pharmacology of Central Nervous System CNS Drugs

Introduction to the Pharmacology of Central Nervous System (CNS) Drugs
Methods for the Study of Central Nervous System (CNS) Pharmacology
Ion Channels & Neurotransmitter Receptors
The Synapse & Synaptic Potentials
Sites of Drug Action
Identification of Central Neurotransmitters
Cellular Organization of the Brain
Central Neurotransmitters

Sedative Hypnotic Drugs

Basic Pharmacology of Sedative Hypnotics
Chemical Classification - Basic Pharmacology of Sedative Hypnotics
Pharmacokinetics - Basic Pharmacology of Sedative Hypnotics
Pharmacodynamics of Benzodiazepines, Barbiturates, & Newer Hypnotics
Tolerance & Dependence - Basic Pharmacology of Sedative Hypnotics
Benzodiazepine Antagonists: Flumazenil
Treatment of Anxiety States
Treatment of Sleep Problems
Other Therapeutic Uses
Clinical Toxicology of Sedative-Hypnotics

The Alcohols

The Alcohols
Basic Pharmacology of Ethanol: Pharmacokinetics
Pharmacodynamics of Acute Ethanol Consumption
Consequences of Chronic Alcohol Consumption
What Can Drunken Worms, Flies, and Mice Tell Us about Alcohol?
Alcohol-Drug Interactions
Clinical Pharmacology of Ethanol
Management of Acute Alcohol Intoxication
Management of Alcohol Withdrawal Syndrome
Treatment of Alcoholism
Pharmacology of Methanol
Pharmacology of Ethylene Glycol

Antiseizure Drugs

Antiseizure Drugs
Drug Development for Epilepsy - Antiseizure Drugs
Basic Pharmacology of Antiseizure Drugs
Drugs Used in Partial Seizures Generalized Tonic-Clonic Seizures
Mephenytoin, Ethotoin, & Phenacemide
Gabapentin & Pregabalin
Retigabine (Ezogabine)
Phensuximide & Methsuximide
Valproic Acid & Sodium Valproate
Seizure Classification - Clinical Pharmacology of Antiseizure Drugs
Therapeutic Strategy - Clinical Pharmacology of Antiseizure Drugs
Management of Epilepsy
Special Aspects of the Toxicology of Antiseizure Drugs

General Anesthetics

General Anesthetics
Mechanism of General Anesthetic Action
Inhaled Anesthetics
Pharmacokinetics - Inhaled Anesthetics
Pharmacodynamics - Inhaled Anesthetics
What Does Anesthesia Represent & Where Does It Work?
Intravenous Anesthetics
Propofol - Intravenous Anesthetics
Fospropofol - Intravenous Anesthetics
Barbiturates - Intravenous Anesthetics
Benzodiazepines - Intravenous Anesthetics
Etomidate - Intravenous Anesthetics
Ketamine - Intravenous Anesthetics
Dexmedetomidine - Intravenous Anesthetics
Opioid Analgesics - Intravenous Anesthetics
Current Clinical Practice - Intravenous Anesthetics

Local Anesthetics

Local Anesthetics
Basic Pharmacology of Local Anesthetics
Historical Development of Local Anesthesia
Clinical Pharmacology of Local Anesthetics
Lipid Resuscitation
Commonly Used Local Anesthetics & Their Applications

Skeletal Muscle Relaxants

Skeletal Muscle Relaxants
Neuromuscular Blocking Drugs
Basic Pharmacology of Neuromuscular Blocking Drugs
Clinical Pharmacology of Neuromuscular Blocking Drugs
Spasmolytic Drugs
Diazepam - Spasmolytic Drugs
Tizanidine - Spasmolytic Drugs
Dantrolene - Spasmolytic Drugs
Botulinum Toxin - Spasmolytic Drugs
Drugs Used to Treat Acute Local Muscle Spasm

Pharmacologic Management of Parkinsonism Other Movement Disorders

Pharmacologic Management of Parkinsonism & Other Movement Disorders
Dopamine Receptor Agonists
Monoamine Oxidase Inhibitors
Catechol-O-Methyltransferase Inhibitors
Acetylcholine-Blocking Drugs
Surgical Procedures - Parkinsonism
Neuroprotective Therapy - Parkinsonism
Gene Therapy - Parkinsonism
General Comments On Drug Management of Patients With Parkinsonism
Drug-Induced Parkinsonism
MPTP & Parkinsonism
Other Movement Disorders

Antipsychotic Agents Lithium

Antipsychotic Agents
The Serotonin Hypothesis of Schizophrenia
The Dopamine Hypothesis of Schizophrenia
The Glutamate Hypothesis of Schizophrenia
Basic Pharmacology of Antipsychotic Agents
Clinical Pharmacology of Antipsychotic Agents
Lithium, Mood Stabilizing Drugs, & Other Treatment For Bipolar Disorder
Basic Pharmacology of Lithium
Clinical Pharmacology of Lithium

Antidepressant Agents

Antidepressant Agents
Pathophysiology of Major Depression
Neurotrophic Hypothesis
Monoamines and Other Neurotransmitters
Neuroendocrine Factors in the Pathophysiology of Depression
Integration of Hypotheses Regarding the Pathophysiology of Depression
Basic Pharmacology of Antidepressants
Clinical Indications - Clinical Pharmacology of Antidepressants
Choosing an Antidepressant - Clinical Pharmacology of Antidepressants
Dosing - Clinical Pharmacology of Antidepressants
Adverse Effects - Clinical Pharmacology of Antidepressants
Overdose - Clinical Pharmacology of Antidepressants
Drug Interactions - Clinical Pharmacology of Antidepressants

Opioid Analgesics Antagonists

Basic Pharmacology of the Opioid Analgesics
Pharmacokinetics - Basic Pharmacology of the Opioid Analgesics
Pharmacodynamics - Basic Pharmacology of the Opioid Analgesics
Clinical Pharmacology of the Opioid Analgesics
Ion Channels & Novel Analgesic Targets
Clinical Use of Opioid Analgesics
Toxicity & Undesired Effects - Clinical Pharmacology of the Opioid Analgesics
Strong Agonists
MILD to Moderate Agonists
Opioids With Mixed Receptor Actions
The Opioid Antagonists

Drugs of Abuse

Drugs of Abuse
Dependence Versus Addiction
Addictive Drugs Increase the Level of Dopamine: Reinforcement
Animal Models in Addiction Research
The Dopamine Hypothesis of Addiction
Dependence: Tolerance & Withdrawal - Drugs of Abuse
Addiction: A Disease of Maladaptive Learning
Nonaddictive Drugs of Abuse
Basic Pharmacology of Drugs of Abuse
Opioids - Drugs That Activate Gio-Coupled Receptors
Cannabinoids - Drugs That Activate Gio-Coupled Receptors
Gamma-Hydroxybutyric Acid - Drugs That Activate Gio-Coupled Receptors
LSD, Mescaline, & Psilocybin
Drugs that Mediate their Effects via Ionotropic Receptors
Drugs that Bind to Transporters of Biogenic Amines
Clinical Pharmacology of Dependence & Addiction

Agents Used in Anemias Hematopoietic Growth Factors

Agents Used in Anemias; Hematopoietic Growth Factors
Sickle Cell Disease and Hydroxyurea
Iron - Agents Used In Anemias
VITAMIN B12 - Agents Used In Anemias
Folic Acid - Agents Used In Anemias
Folic Acid Supplementation: A Public Health Dilemma
Hematopoietic Growth Factors
Erythropoietin - Hematopoietic Growth Factors
Myeloid Growth Factors
Megakaryocyte Growth Factors

Drugs Used in Disorders of Coagulation

Drugs Used in Disorders of Coagulation
Mechanisms of Blood Coagulation
Blood Coagulation Cascade
Basic Pharmacology of the Anticoagulant Drugs
Indirect Thrombin Inhibitors
Oral Direct Factor XA Inhibitors
Direct Thrombin Inhibitors
Warfarin & Other Coumarin Anticoagulants
Basic Pharmacology of the Fibrinolytic Drugs
Basic Pharmacology of Antiplatelet Agents
Clinical Pharmacology of Drugs Used to Prevent Clotting
Drugs Used in Bleeding Disorders

Agents Used in Dyslipidemia

Agents Used in Dyslipidemia
Normal Lipoprotein Metabolism
Lipoprotein Disorders
The Primary Hypertriglyceridemias
The Primary Hypercholesterolemias
Secondary Hyperlipoproteinemia
Competitive Inhibitors of HMG-COA Reductase (Reductase Inhibitors; 'Statins')
NIACIN (Nicotinic Acid)
Fibric Acid Derivatives (FIBRATES)
Bile Acid-Binding Resins
Inhibitors of Intestinal Sterol Absorption
CETP Inhibitors and Treatment With Drug Combinations

Nonsteroidal Anti Inflammatory Drugs Disease Modifying Antirheumatic Drugs Nonopioid Analgesics Drugs Used in Gout

The Immune Response
Therapeutic Strategies
Nonsteroidalanti Inflammatory Drugs
Nonacetylated Salicylates
Cox-2 Selective Inhibitors
Nonselective Cox Inhibitors
Choice of NSAID
Disease Modifying Antirheumatic Drugs
Chloroquine & Hydroxychloroquine
Mycophenolate Mofetil
TNF-?-Blocking Agents
Combination Therapy With Dmards
Drugs Used In Gout
Nsaids In Gout
Uricosuric Agents
Interleukin-1 Inhibitors


Hypothalamic Pituitary Hormones

Hypothalamic & Pituitary Hormones
Anterior Pituitary & Hypothalamic Hormone Receptors
Growth Hormone (Somatotropin)
Treatment of Obesity
Growth Hormone Antagonists
Gonadotropins & Human Chorionic Gonadotropin
Gonadotropin-Releasing Hormone & Its Analogs
GNRH Receptor Antagonists
Dopamine Agonists
Oxytocin Antagonist
Vasopressin (Antidiuretic Hormone, ADH)
Vasopressin Antagonists

Thyroid Antithyroid Drugs

Thyroid Physiology
Thyroid Hormones
Antithyroid Agents
Anion Inhibitors
Radioactive Iodine
Adrenoceptor-Blocking Agents
Nontoxic Goiter
Thyroid Neoplasms

Adrenocorticosteroids And Adrenocortical Antagonists

The Naturally Occurring Glucocorticoids; Cortisol (Hydrocortisone)
Synthetic Corticosteroids
Clinical Pharmacology - Synthetic Corticosteroids
Toxicity - Synthetic Corticosteroids
Contraindications & Cautions - Synthetic Corticosteroids
Selection of Drug & Dosage Schedule - Synthetic Corticosteroids
Mineralocorticoids (Aldosterone, Deoxycorticosterone, Fludrocortisone)
Adrenal Androgens
Synthesis Inhibitors & Glucocorticoid Antagonists
Mineralocorticoid Antagonists

The Gonadal Hormones Inhibitors

Disturbances in Ovarian Function
The Estrogens
Physiologic Effects - The Estrogens
Clinical Uses - The Estrogens
Adverse Effects - The Estrogens
Preparations & Dosages - The Estrogens
The Progestins
Other Ovarian Hormones
Hormonal Contraception
Pharmacologic Effects - Hormonal Contraception
Clinical Uses - Hormonal Contraception
Adverse Effects - Hormonal Contraception
Contraindications & Cautions - Hormonal Contraception
Contraception with Progestins Alone - Hormonal Contraception
Tamoxifen & Related Partial Agonist Estrogens
Other Inhibitors
Ovulation-Inducing Agents
The Testis
Androgens & Anabolic Steroids
Metabolism - The Testis
Androgen Suppression & Antiandrogens
Chemical Contraception in Men

Pancreatic Hormones Antidiabetic Drugs

The Endocrine Pancreas
Characteristics of Available Insulin Preparations
Insulin Delivery Systems
Treatment with Insulin, Benefit of Glycemic Control in Diabetes Mellitus
Insulin Regimens
Benefits of Tight Glycemic Control in Diabetes
Insulin Treatment of Special Circumstances
Complications of Insulin Therapy
Oral Antidiabetic Agents
Insulin Secretagogues: Sulfonylureas
First-Generation Sulfonylureas
Second-Generation Sulfonylureas
Insulin Secretagogue: Meglitinide
Insulin Secretagogue: D-Phenylalanine Derivative
Alpha-Glucosidase Inhibitors
Bile Acid Sequestrants
Amylin Analog
Glucagon-Like Polypeptide-1 (GLP-1) Receptor Agonists
Dipeptidyl Peptidase-4 (DPP-4) Inhibitors
Combination Therapy-Oral Antidiabetic Agents & Injectable Medication
Islet Amyloid Polypeptide IAPP, Amylin

Agents That Affect Bone Mineral Homeostasis

Basic Pharmacology
Parathyroid Hormone - Principal Hormonal Regulators of Bone Mineral Homeostasis
Vitamin D - Principal Hormonal Regulators of Bone Mineral Homeostasis
Fibroblast Growth Factor 23 - Principal Hormonal Regulators of Bone Mineral Homeostasis
Interaction of PTH, FGF23, & Vitamin D
Secondary Hormonal Regulators of Bone Mineral Homeostasis
Newer Therapies for Osteoporosis
Nonhormonal Agents Affecting Bone Mineral Homeostasis
Clinical Pharmacology - Agents That Affect Bone Mineral Homeostasis
Abnormal Serum Calcium & Phosphate Levels
Specific Disorders Involving Bone Mineral-Regulating Hormones
Other Disorders of Bone Mineral Homeostasis

Introduction To Antimicrobial Agents

Introduction to Antimicrobial Agents


Beta Lactam OtherCell Wall Membrane Active Antibiotics

Beta Lactam Compounds: Penicillins
Cephalosporins & Cephamycins
Monobactams - Beta Lactam Drugs
Beta-Lactamase Inhibitors (Clavulanic Acid, Sulbactam, & Tazobactam) - Beta Lactam Drugs
Carbapenems - Beta Lactam Drugs
Glycopeptide Antibiotics
Other Cell Wall or Membrane Active Agents

Tetracyclines Macrolides Clindamycin Chloramphenicol Streptogramins Oxazolidinones

Erythromycin - Macrolides
Clarithromycin - Macrolides
Azithromycin - Macrolides
Ketolides - Macrolides

Aminoglycosides Spectinomycin

General Properties of Aminoglycosides
Neomycin & Kanamycin

SulfonamidesTrimethoprim Quinolones

Sulfonamides - Antifolate Drugs
Trimethoprim & Trimethoprim-Sulfamethoxazole Mixtures - Antifolate Drugs
Dna Gyrase Inhibitors : Fluoroquinolones

Antimycobacterial Drugs

Antimycobacterial Drugs
Drugs Used In Tuberculosis
Isoniazid - Drugs Used In Tuberculosis
Rifampin - Drugs Used In Tuberculosis
Ethambutol - Drugs Used In Tuberculosis
Pyrazinamide - Drugs Used In Tuberculosis
Streptomycin - Drugs Used In Tuberculosis
Second-Line Drugs for Tuberculosis
Drugs Active Against Atypical Mycobacteria
Drugs Used in Leprosy

Antifungal Agents

Antifungal Agents
Amphotericin B
Oral Systemic Antifungal Drugs for Mucocutaneous Infections
Topical Antifungal Therapy

Antiviral Agents

Antiviral Agents
Agents to Treat Herpes Simplex Virus HSV & Varicella Zoster Virus VZV Infections
Agents to Treat Cytomegalovirus CMV Infections
Antiretroviral Agents
Nucleoside & Nucleotide Reverse Transcriptase Inhibitors
Nonnucleoside Reverse Transcriptase Inhibitors
Protease Inhibitors
Entry Inhibitors
Integrase Strand Transfer Inhibitors
New & Investigational Antiretroviral Agents
Treatment of Hepatitis B Virus Infection
Treatment of Hepatitis C Infection
Anti Influenza Agents
Other Antiviral Agents

Miscellaneous Antimicrobial Agents DisinfectantsAntiseptics Sterilants

Urinary Antiseptics
Disinfectants, Antiseptics, & Sterilants
Alcohols - Disinfectants, Antiseptics, & Sterilants
Chlorhexidine - Disinfectants, Antiseptics, & Sterilants
Halogens - Disinfectants, Antiseptics, & Sterilants
Phenolics - Disinfectants, Antiseptics, & Sterilants
Quaternary Ammonium Compounds
Aldehydes - Disinfectants, Antiseptics, & Sterilants
Superoxidized Water - Disinfectants, Antiseptics, & Sterilants
Peroxygen Compounds - Disinfectants, Antiseptics, & Sterilants
Heavy Metals - Disinfectants, Antiseptics, & Sterilants
Sterilants - Disinfectants, Antiseptics, & Sterilants
Preservatives - Disinfectants, Antiseptics, & Sterilants

Clinical Use of Antimicrobial Agents

Clinical Use of Antimicrobial Agents
Empiric Antimicrobial Therapy
Antimicrobial Therapy of Infections with Known Etiology
Management of Antimicrobial Drug Toxicity
Antimicrobial Drug Combinations
Antimicrobial Prophylaxis

Antiprotozoal Drugs

Parasite Life Cycle - Malaria
Drug Classification - Malaria
Chemoprophylaxis & Treatment - Malaria
Malaria: Chloroquine
Other Quinolines - Malaria
Artemisinin & Its Derivatives - Malaria
Quinine & Quinidine - Malaria
Mefloquine - Malaria
Primaquine - Malaria
Atovaquone - Malaria
Inhibitors of Folate Synthesis - Malaria
Antibiotics - Malaria
Halofantrine & Lumefantrine - Malaria
Treatment of Specific Forms of Amebiasis
Metronidazole & Tinidazole
Diloxanide Furoate
Paromomycin Sulfate
Emetine & Dehydroemetine
Pentamidine Antiprotozoal Drugs
Sodium Stibogluconate Antiprotozoal Drugs
Nitazoxanide Antiprotozoal Drugs
Other Drugs for Trypanosomiasis & Leishmaniasis

Clinical Pharmacology of the Antihelminthic Drugs

Chemotherapy of Helminthic Infections
Diethylcarbamazine Citrate
Metrifonate (Trichlorfon)
Pyrantel Pamoate

Cancer Chemotherapy

Cancer Chemotherapy
Causes of Cancer
Cancer Treatment Modalities
Role of Cell Cycle Kinetics & Anticancer Effect
Drug Resistance - Cancer Chemotherapy
Alkylating Agents - Pharmacology of Cancer Chemotherapeutic Drugs
Nonclassic Alkylating Agents
Platinum Analogs
Deoxycytidine Analogs
Purine Antagonists
Vinca Alkaloids
Taxanes & Related Drugs
Antitumor Antibiotics
Miscellaneous Anticancer Drugs
Clinical Pharmacology of Cancer Chemotherapeutic Drugs
The Leukemias
Hodgkin’s Lymphoma
Non-Hodgkin’s Lymphoma
Multiple Myeloma
Breast Cancer
Gastrointestinal Cancers
Lung Cancer
Ovarian Cancer
Testicular Cancer
Malignant Melanoma
Brain Cancer
Secondary Malignancies & Cancer Chemotherapy


Normal Immune Responses
Abnormal Immune Responses
Glucocorticoids - Immunosuppressive Agents
Calcineurin Inhibitors - Immunosuppressive Agents
Mammalian Target Of Rapamycin (mTOR) Inhibitors
Mycophenolate Mofetil - Immunosuppressive Agents
Immunomodulatory Derivatives Of Thalidomide (IMiDs)
Cytotoxic Agents - Immunosuppressive Agents
Immunosuppressive Antibodies
Monoclonal Antibodies (MABs)
Clinical Uses of Immunosuppressive Drugs
Immunologic Reactions to Drugs & Drug Allergy
Immediate (Type I) Drug Allergy
Autoimmune (Type Ii) Reactions to Drugs
Serum Sickness & Vasculitic (Type III) Reactions


Introduction to Toxicology Occupational Environmental

Introduction to Toxicology: Occupational & Environmental
Toxicologic Terms & Definitions
Environmental Considerations - Toxicology
Air Pollutants - Specific Chemicals
Solvents - Specific Chemicals
Pesticides - Specific Chemicals
Herbicides - Specific Chemicals
Environmental Pollutants - Specific Chemicals
Metals - Specific Chemicals

Heavy Metal Intoxication Chelators

Toxicology of Lead
Major Forms of Lead Intoxication
Treatment - Toxicology of Lead
Toxicology of Arsenic
Pharmacokinetics, Pharmacodynamics - Toxicology of Arsenic
Major Forms of Arsenic Intoxication
Toxicology of Mercury
Pharmacokinetics - Toxicology of Mercury
Major Forms of Mercury Intoxication
Treatment - Toxicology of Mercury
Pharmacology of Chelators
Dimercaprol (2,3-Dimercaptopropanol, BAL)
Succimer (Dimercaptosuccinic ACID, DMSA)
Edetate Calcium Disodium (Ethylenediaminetetraacetic Acid, EDTA)
Unithiol (Dimercaptopropanesulfonic Acid, DMPS)
Penicillamine (D-Dimethlcysteine)
Prussian Blue (Ferric Hexacyanoferrate)

Management of the Poisoned Patient

Management of the Poisoned Patient
Toxicokinetics & Toxicodynamics
Approach to the Poisoned Patient
Initial Management of the Poisoned Patient
Toxic Syndromes: Acetaminophen
Toxic Syndromes: Amphetamines & Other Stimulants
Toxic Syndromes: Anticholinergic Agents
Toxic Syndromes: Antidepressants
Toxic Syndromes: Antipsychotics
Toxic Syndromes: Aspirin (Salicylate)
Toxic Syndromes: Beta Blockers
Toxic Syndromes: Calcium Channel Blockers
Toxic Syndromes: Cholinesterase Inhibitors
Toxic Syndromes: Cyanide
Toxic Syndromes: Digoxin
Toxic Syndromes: Ethanol & Sedative-Hypnotic Drugs
Toxic Syndromes: Ethylene Glycol & Methanol
Toxic Syndromes: Rattlesnake Envenomation
Toxic Syndromes: Theophylline


Special Aspects of Perinatal Pediatric Pharmacology

Drug Therapy in Pregnancy
Drug Therapy in Infants & Children
Pediatric Dosage Forms & Compliance
Drug Use During Lactation
Pediatric Drug Dosage

Special Aspects of Geriatric Pharmacology

Special Aspects of Geriatric Pharmacology
Pharmacologic Changes Associated With Aging
Central Nervous System Drugs
Cardiovascular Drugs
Antimicrobial Drugs
Anti-Inflammatory Drugs
Ophthalmic Drugs
Adverse Drug Reactions in the Elderly
Practical Aspects of Geriatric Pharmacology

Dermatologic Pharmacology

Dermatologic Pharmacology
Dermatologic Vehicles
Antibacterial Agents
Antifungal Agents
Oral Antifungal Agents
Topical Antiviral Agents
Agents Affecting Pigmentation
Acne Preparations
Drugs for Psoriasis
Biologic Agents
Anti Inflammatory Agents
Keratolytic & Destructive Agents
Antipruritic Agents
Trichogenic & Antitrichogenic Agents
Antineoplastic Agents
Antiseborrhea Agents

Drugs Used in the Treatment of Gastrointestinal Diseases

Drugs Used in the Treatment of Gastrointestinal Diseases
Physiology of Acid Secretion - Agents that Reduce Intragastric Acidity
Antacids - Agents that Reduce Intragastric Acidity
H2-Receptor Antagonists - Agents that Reduce Intragastric Acidity
Proton Pump Inhibitors
Mucosal Protective Agents
Drugs Stimulating Gastrointestinal Motility
Antidiarrheal Agents
Drugs Used in the Treatment of Irritable Bowel Syndrome
Antiemetic Agents
Drugs Used to Treat Inflammatory Bowel Disease
Purine Analogs: Azathioprine & 6-Mercaptopurine
Anti-Tumor Necrosis Factor Therapy
Anti-Integrin Therapy
Pancreatic Enzyme Supplements
Bile Acid Therapy For Gallstones
Drugs Used to Treat Variceal Hemorrhage

Dietary Supplements Herbal Medications

Dietary Supplements & Herbal Medications
Historical & Regulatory Factors - Dietary Supplements & Herbal Medications
Clinical Aspects of the Use of Botanicals
Botanical Substances: Echinacea (Echinacea Purpurea)
Botanical Substances: Garlic (Allium Sativum)
Botanical Substances: Ginkgo (Ginkgo Biloba)
Botanical Substances: Ginseng
Botanical Substances: Milk Thistle (Silybum Marianum)
St. John’s Wort (Hypericumperforatum)
Saw Palmetto (Serenoa Repens Orsabal Serrulata)
Coenzyme Q10

Rational Prescribing Prescription Writing

Rational Prescribing
The Prescription
Prescribing Errors
Who May Prescribe?
Socioeconomic Factors
The Cost of Prescriptions

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