NITAZOXANIDE
Nitazoxanide is a
nitrothiazolyl-salicylamide prodrug. Nitazoxanide was recently approved in the
USA for use against Giardia lamblia
and Cryptosporidium parvum. It is
rapidly absorbed and converted to tizoxanide and tizoxanide conjugates, which
are subsequently excreted in both urine and feces. The active metabolite,
tizox-anide, inhibits the pyruvate-ferredoxin oxidoreductase pathway.
Nitazoxanide appears to have activity against metronidazole-resistant protozoal
strains and is well tolerated. Unlike metronida-zole, nitazoxanide and its
metabolites appear to be free of mutagenic effects. Other organisms that may be
susceptible to nitazoxanide include E
histolytica, Helicobacter pylori, Ascaris lum-bricoides, several tapeworms,
and Fasciola hepatica. The
recom-mended adult dosage is 500 mg twice daily for 3 days.
Related Topics
Privacy Policy, Terms and Conditions, DMCA Policy and Compliant
Copyright © 2018-2024 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.