DRUG CLASSIFICATION
Several
classes of antimalarial drugs are available (Table 52–1 and Figure 52–2). Drugs
that eliminate developing or dormant liver forms are called tissue schizonticides; those that act
on erythro-cytic parasites are blood
schizonticides; and those that kill sexual stages and prevent transmission
to mosquitoes are gametocides. No
single available agent can reliably effect a radical cure, ie, eliminate both hepatic and erythrocytic stages.
Few available agents are causal
prophylactic drugs, ie, capable of preventing erythro-cytic infection.
However, all effective chemoprophylactic agents kill erythrocytic parasites
before they increase sufficiently in num-ber to cause clinical disease.
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