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Chapter: Basic & Clinical Pharmacology - Antiprotozoal Drugs

Drug Classification - Malaria

Drugs that eliminate developing or dormant liver forms are called tissue schizonticides; those that act on erythro-cytic parasites are blood schizonticides; and those that kill sexual stages and prevent transmission to mosquitoes are gametocides.

DRUG CLASSIFICATION

Several classes of antimalarial drugs are available (Table 52–1 and Figure 52–2). Drugs that eliminate developing or dormant liver forms are called tissue schizonticides; those that act on erythro-cytic parasites are blood schizonticides; and those that kill sexual stages and prevent transmission to mosquitoes are gametocides. No single available agent can reliably effect a radical cure, ie, eliminate both hepatic and erythrocytic stages. Few available agents are causal prophylactic drugs, ie, capable of preventing erythro-cytic infection. However, all effective chemoprophylactic agents kill erythrocytic parasites before they increase sufficiently in num-ber to cause clinical disease.





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