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Chapter: Basic & Clinical Pharmacology : Antiprotozoal Drugs

Paromomycin Sulfate

Paromomycin sulfate is an aminoglycoside antibiotic that is not significantly absorbed from the gastrointestinal tract.

PAROMOMYCIN SULFATE

Paromomycin sulfate is an aminoglycoside antibiotic that is not significantly absorbed from the gastrointestinal tract. It is used only as a luminal amebicide and has no effect against extraintestinal amebic infections. The small amount absorbed is slowly excreted unchanged, mainly by glomerular fil-tration. However, the drug may accumulate with renal insuffi-ciency and contribute to renal toxicity. Paromomycin is an effective luminal amebicide that appears to have similar efficacy and probably less toxicity than other agents; in a recent study, it was superior to diloxanide furoate in clearing asymptomatic infec-tions. Adverse effects include occasional abdominal distress and diarrhea. Parenteral paromomycin is now used to treat visceral leishmaniasis and is discussed separately in the text that follows.


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Basic & Clinical Pharmacology : Antiprotozoal Drugs : Paromomycin Sulfate |


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