RELATION BETWEEN DRUG DOSE &
CLINICAL RESPONSE
We
have dealt with receptors as molecules and shown how receptors can
quantitatively account for the relation between dose or concentration of a
drug and pharmacologic responses, at least in an idealized system. When faced
with a patient who needs treatment, the prescriber must make a choice among a
variety of possible drugs and devise a dosage regimen that is likely to produce
maximal benefit and minimal toxicity. To make rational therapeutic decisions,
the prescriber must understand how drug-receptor interactions underlie the
relations between dose and response in patients, the nature and causes of
variation in pharmacologic responsiveness, and the clinical implications of
selectivity of drug action.
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