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Chapter: Basic & Clinical Pharmacology : Dietary Supplements & Herbal Medications

Clinical Aspects of the Use of Botanicals

Many United States consumers have embraced the use of dietary supplements as a “natural” approach to their health care.

CLINICAL ASPECTS OF THE USE OF BOTANICALS

Many United States consumers have embraced the use of dietary supplements as a “natural” approach to their health care. Unfortunately, misconceptions regarding safety and efficacy of the agents are common, and the fact that a substance can be called “natural” does not of course guarantee its safety. In fact, theseproducts may be inherently inert, toxic, or may have been adulter-ated, misbranded, or contaminated either intentionally or unin-tentionally in a variety of ways.

 

Adverse effects have been documented for a variety of dietary supplements; however, under-reporting of adverse effects is likely since consumers do not routinely report, and do not know how to report an adverse effect if they suspect that the event was caused by consumption of a supplement. Furthermore, chemical analysis is rarely performed on the products involved, including those products that are described in the literature as being linked to an adverse event. This leads to confusion about whether the primary ingredient or an adulterant caused the adverse effect. In some cases, the chemical constituents of the herb can clearly lead to toxicity. Some of the herbs that should be used cautiously or not at all are listed in Table 64–1.

 


An important risk factor in the use of dietary supplements is the lack of adequate testing for drug interactions. Since botanicals may contain hundreds of active and inactive ingredients, it is very difficult and costly to study potential drug interactions when they are combined with other medications. This may present signifi-cant risks to patients.

 

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