The therapeutic use of botulinum toxin for ophthalmic purposes and for local muscle spasm was mentioned. Local facial injections of botulinum toxin are widely used for the short-term treatment (1–3 months per treatment) of wrinkles associated with aging around the eyes and mouth. Local injection of botuli-num toxin has also become a useful treatment for generalized spastic disorders (eg, cerebral palsy). Most clinical studies to date have involved administration in one or two limbs, and the benefits appear to persist for weeks to several months after a single treat-ment. Most studies have used type A botulinum toxin, but type B is also available.