DIAZEPAM
As
described in, benzodiazepines facilitate the action of GABA in the central
nervous system. Diazepam acts at GABAA synapses, and its action in
reducing spasticity is at least partly mediated in the spinal cord because it
is somewhat effective in patients with cord transection. Although diazepam can
be used in patients with muscle spasm of almost any origin (including local
muscle trauma), it also produces sedation at the doses required to reduce
muscle tone. The initial dosage is 4 mg/d, and it is gradu-ally increased to a
maximum of 60 mg/d. Other benzodiazepines have been used as spasmolytics (eg,
midazolam), but clinical expe-rience with them is limited.
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