Phensuximide & Methsuximide

PHENSUXIMIDE & METHSUXIMIDE

Phensuximide (no longer readily available) and methsuximide are phenylsuccinimides that were developed and marketed before ethosuximide. They are used primarily as anti-absence drugs. Methsuximide is generally considered more toxic, and phensuxim-ide less effective, than ethosuximide. Unlike ethosuximide, these two compounds have some activity against maximal electroshock seizures, and methsuximide has been used for partial seizures by some investigators.