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Chapter: Basic & Clinical Pharmacology : Antiseizure Drugs

Phensuximide & Methsuximide

Phensuximide (no longer readily available) and methsuximide are phenylsuccinimides that were developed and marketed before ethosuximide.

DRUGS USED IN GENERALIZED SEIZURES

PHENSUXIMIDE & METHSUXIMIDE

Phensuximide (no longer readily available) and methsuximide are phenylsuccinimides that were developed and marketed before ethosuximide. They are used primarily as anti-absence drugs. Methsuximide is generally considered more toxic, and phensuxim-ide less effective, than ethosuximide. Unlike ethosuximide, these two compounds have some activity against maximal electroshock seizures, and methsuximide has been used for partial seizures by some investigators.


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Basic & Clinical Pharmacology : Antiseizure Drugs : Phensuximide & Methsuximide |


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