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Chapter: Basic & Clinical Pharmacology : Antihypertensive Agents

Angiotensin Receptor-Blocking Agents

Losartan and valsartan were the first marketed blockers of theangiotensin II type 1 (AT1) receptor.

ANGIOTENSIN RECEPTOR-BLOCKING AGENTS

Losartan and valsartan were the first marketed blockers of theangiotensin II type 1 (AT1) receptor. Candesartan, eprosartan,irbesartan, telmisartan, and olmesartan are also available. Theyhave no effect on bradykinin metabolism and are therefore more selective blockers of angiotensin effects than ACE inhibitors. They also have the potential for more complete inhibition of angio-tensin action compared with ACE inhibitors because there are enzymes other than ACE that are capable of generating angio-tensin II. Angiotensin receptor blockers provide benefits similar to those of ACE inhibitors in patients with heart failure and chronic kidney disease. Losartan’s pharmacokinetic parameters are listed in Table 11–2. The adverse effects are similar to those described for ACE inhibitors, including the hazard of use during pregnancy. Cough and angioedema can occur but are less common with angiotensin receptor blockers than with ACE inhibitors.



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Basic & Clinical Pharmacology : Antihypertensive Agents : Angiotensin Receptor-Blocking Agents |


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