Reduction of thyroid
activity and hormone effects can be accom-plished by agents that interfere with
the production of thyroid hormones, by agents that modify the tissue response
to thyroid hormones, or by glandular destruction with radiation or surgery.
Goitrogens are agents that suppress secretion of T3 and T4 to sub-normal levels and thereby increase
TSH, which in turn produces glandular enlargement (goiter). The antithyroid
compounds used clinically include the thioamides, iodides, and radioactive