ADRENOCEPTOR-BLOCKING AGENTS
Beta
blockers without intrinsic sympathomimetic activity (eg, metoprolol,
propranolol, atenolol) are effective therapeutic adjuncts in the management of
thyrotoxicosis since many of these symptoms mimic those associated with
sympathetic stimulation. Propranolol has been the β blocker most widely studied and
used in the therapy of thyrotoxicosis. Beta blockers cause clinical improvement
of hyperthyroid symptoms but do not typically alter thyroid hormone levels.
Propranolol at doses greater than 160 mg/d may also reduce T3
levels approximately 20% by inhibiting the peripheral conversion of T4
to T3.
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