OVARIAN CANCER
In the majority of
patients, ovarian cancer remains occult and becomes symptomatic only after it
has already metastasized to the peritoneal cavity. At this stage, it usually
presents with malignant ascites. It is important to accurately stage this
cancer with laparos-copy, ultrasound, and CT scanning. Patients with stage I
disease appear to benefit from whole-abdomen radiotherapy and may receive
additional benefit from combination chemotherapy with cisplatin and
cyclophosphamide.
Combination
chemotherapy is the standard approach to stageand stage IV disease. Randomized clinical
studies have shown that the combination of paclitaxel and cisplatin provides
survival benefit compared with the previous standard combination of cis-platin
plus cyclophosphamide. More recently, carboplatin plus paclitaxel has become
the treatment of choice. In patients who present with recurrent disease, the
topoisomerase I inhibitor topo-tecan, the alkylating agent altretamine, and
liposomal doxorubicin are used as single agent monotherapy.
Related Topics
Privacy Policy, Terms and Conditions, DMCA Policy and Compliant
Copyright © 2018-2023 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.