actions of serotonin, like those of histamine, can be antagonized in several
ways. Such antagonism is clearly desirable in those rare patients who have
carcinoid tumor and may also be valuable in certain other conditions.
noted, serotonin synthesis can be inhibited by p-chlorophenylalanine and p-chloroamphetamine.
are too toxic for general use. Storage of serotonin can be inhibited by the use
of reserpine, but the sympatholytic effects of this drug and the high levels of circulating serotonin
that result from release prevent its use in carcinoid. Therefore, receptor
blockade is the major therapeutic approach to conditions of serotonin excess.