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BASIC PHARMACOLOGY OF DRUGS USED TO TREAT ANGINA
Drug Action in Angina
The three drug groups traditionally used in angina (organic nitrates, calcium channel blockers, and β blockers) decrease myocardial oxygenrequirement by decreasing the determinants of oxygen demand(heart rate, ventricular volume, blood pressure, and contractility). In some patients, the nitrates and the calcium channel blockers may cause a redistribution of coronary flow and increase oxygen delivery to ischemic tissue. In variant angina, these two drug groups also increase myocardial oxygen delivery by reversing coronary artery spasm. The newer drugs, represented by ranolazine and ivabradine, are discussed later.
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