Chapter: Basic & Clinical Pharmacology : Vasodilators & the Treatment of Angina Pectoris

Basic Pharmacology of Drugs Used to Treat Angina

The three drug groups traditionally used in angina (organic nitrates, calcium channel blockers, and β blockers) decrease myocardial oxygenrequirement by decreasing the determinants of oxygen demand(heart rate, ventricular volume, blood pressure, and contractility).

BASIC PHARMACOLOGY OF DRUGS USED TO TREAT ANGINA

Drug Action in Angina

The three drug groups traditionally used in angina (organic nitrates, calcium channel blockers, and β blockers) decrease myocardial oxygenrequirement by decreasing the determinants of oxygen demand(heart rate, ventricular volume, blood pressure, and contractility). In some patients, the nitrates and the calcium channel blockers may cause a redistribution of coronary flow and increase oxygen delivery to ischemic tissue. In variant angina, these two drug groups also increase myocardial oxygen delivery by reversing coronary artery spasm. The newer drugs, represented by ranolazine and ivabradine, are discussed later.

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Basic & Clinical Pharmacology : Vasodilators & the Treatment of Angina Pectoris : Basic Pharmacology of Drugs Used to Treat Angina |