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Doxycycline has recently been shown to have significant macro-filaricidal activity against W bancrofti, suggesting better activity than any other available drug against adult worms. Activity is also seen against onchocerciasis. Doxycycline acts indirectly, by killing Wolbachia, an intracellular bacterial symbiont of filarial parasites.It may prove to be an important drug for filariasis, both for treat-ment of active disease and in mass chemotherapy campaigns.
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