Chapter: Basic & Clinical Pharmacology : Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics,& Drugs Used in Gout

Nonacetylated Salicylates

These drugs include magnesium choline salicylate, sodium salicy-late, and salicyl salicylate.

NONACETYLATED SALICYLATES

These drugs include magnesium choline salicylate, sodium salicy-late, and salicyl salicylate. All nonacetylated salicylates are effective anti-inflammatory drugs, although they may be less effective anal-gesics than aspirin. Because they are much less effective than aspirin as COX inhibitors and they do not inhibit platelet aggrega-tion, they may be preferable when COX inhibition is undesirable such as in patients with asthma, those with bleeding tendencies, and even (under close supervision) those with renal dysfunction.

The nonacetylated salicylates are administered in doses up to 3–4 g of salicylate a day and can be monitored using serum salicy-late measurements.

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Basic & Clinical Pharmacology : Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics,& Drugs Used in Gout : Nonacetylated Salicylates |