NONACETYLATED SALICYLATES
These
drugs include magnesium choline salicylate, sodium salicy-late, and salicyl
salicylate. All nonacetylated salicylates are effective anti-inflammatory
drugs, although they may be less effective anal-gesics than aspirin. Because
they are much less effective than aspirin as COX inhibitors and they do not
inhibit platelet aggrega-tion, they may be preferable when COX inhibition is
undesirable such as in patients with asthma, those with bleeding tendencies,
and even (under close supervision) those with renal dysfunction.
The
nonacetylated salicylates are administered in doses up to 3–4 g of salicylate a
day and can be monitored using serum salicy-late measurements.
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