Chapter: Basic & Clinical Pharmacology : Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics,& Drugs Used in Gout

Cyclophosphamide

Cyclophosphamide is a synthetic DMARD. Its major active metabolite is phosphoramide mustard, which cross-links DNA to prevent cell replication.

CYCLOPHOSPHAMIDE

Mechanism of Action

Cyclophosphamide is a synthetic DMARD. Its major active metabolite is phosphoramide mustard, which cross-links DNA to prevent cell replication. It suppresses T-cell and B-cell function by 30–40%; T-cell suppression correlates with clinical response in the rheumatic diseases.

Indications

Cyclophosphamide is active against rheumatoid arthritis when given orally at dosages of 2 mg/kg/d but not intravenously. It is used regularly to treat systemic lupus erythematosus, vasculitis, Wegener’s granulomatosis, and other severe rheumatic diseases.

Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail

Basic & Clinical Pharmacology : Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics,& Drugs Used in Gout : Cyclophosphamide |