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Chapter: Basic & Clinical Pharmacology : Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics,& Drugs Used in Gout

Cyclophosphamide

Cyclophosphamide is a synthetic DMARD. Its major active metabolite is phosphoramide mustard, which cross-links DNA to prevent cell replication.

CYCLOPHOSPHAMIDE

Mechanism of Action

Cyclophosphamide is a synthetic DMARD. Its major active metabolite is phosphoramide mustard, which cross-links DNA to prevent cell replication. It suppresses T-cell and B-cell function by 30–40%; T-cell suppression correlates with clinical response in the rheumatic diseases.

Indications

Cyclophosphamide is active against rheumatoid arthritis when given orally at dosages of 2 mg/kg/d but not intravenously. It is used regularly to treat systemic lupus erythematosus, vasculitis, Wegener’s granulomatosis, and other severe rheumatic diseases.


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Basic & Clinical Pharmacology : Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics,& Drugs Used in Gout : Cyclophosphamide |


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