TOPICAL ANTIVIRAL AGENTS
Acyclovir, valacyclovir,
penciclovir, and famciclovir are synthetic guanine analogs with inhibitory
activity against members of the herpesvirus family, including herpes simplex
types 1 and 2. Topical acyclovir (Zovirax) is available as a 5% ointment;
topical penciclovir (Denavir), as a 1% cream for the treatment of recurrentorolabial
herpes simplex virus infection in immunocompetent adults. Adverse local
reactions to acyclovir and penciclovir may include pruritus and mild pain with
transient stinging or burning.
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