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Chapter: Basic & Clinical Pharmacology : Agents Used in Cardiac Arrhythmias

Propafenone (Subgroup 1C)

Propafenone has some structural similarities to propranolol and possesses weak β-blocking activity.

PROPAFENONE (SUBGROUP 1C)

Propafenone has some structural similarities to propranolol and possesses weak β-blocking activity. Its spectrum of action is very similar to that of quinidine, but it does not prolong the action potential. Its sodium channel-blocking kinetics are similar to that of flecainide. Propafenone is metabolized in the liver, with an  average half-life of 5–7 hours. The usual daily dosage of propafenone is 450–900 mg in three divided doses. The drug is used primarily for supraventricular arrhythmias. The most com-mon adverse effects are a metallic taste and constipation; arrhyth-mia exacerbation can also occur.

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Basic & Clinical Pharmacology : Agents Used in Cardiac Arrhythmias : Propafenone (Subgroup 1C) |


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