Essential Clinical Immunology

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Essential Clinical Immunology

Essential Clinical Immunology



Basic Components of the Immune System


Basic Components of the Immune System
Antigens
Antibody
T Cells and their Receptors
Major Histocompatibility Complex
Adhesion Molecules
Cytokines
Initiation of the Immune Response
Antibody Production
Functional Components of the Immune System
Tissue Damage Pathways: Hypersensitivity Reactions

Immunological Techniques


Antibody Production
Immunological Assays
Lymphocytic Assays
Fluorescein-Activated Cell Sorter
Lymphocyte Proliferation Assays
DNA Technology Assays

Immune Regulation


Immuno suppression: Immunosuppressive Drugs
Antibodies and Other Immunosuppressive Methods
Immunopotentiation
Cytokine Immunomodulation
Cellular Vaccines and Modulations There of Dendritic Cell Vaccines

Immunological Aspects of Infection


Non Specific Resistance - Immunological Aspects of Infection
Adaptive Immunity
Bacterial Infection
Bacterial Superantigens
Bacterial Evasion of Immune Defense
Viral Infections
Fungal Infection
Parasitic Infection

Immunological Aspects of Immunodeficiency Diseases


Immunological Aspects of Immunodeficiency Diseases
Defects in Anatomical or Physiological Barriers to Infection
Disorders Characterized By Antibody Deficiency
Clinical Manifestations of Antibody Deficiency
Major Categories of Antibody Deficiency
Defects in Cell-Mediated Immunity (T-Cell Dependent Immunity)
Manifestations of T-Cell Deficiency
Major Categories of Combined Immunodeficiency
Immunological and Molecular Classification of SCID
Treatment of SCID
DiGeorgeís Syndrome (Thymic Aplasia)
Phagocyte Deficiencies
Neutropenia - Phagocyte Deficiencies
Defects in Leucocyte Migration - Phagocyte Deficiencies
Defects in Bacterial Killing - Phagocyte Deficiencies
Defects in Killing of Intracellular Bacteria by Activated Macrophages
Complex Immunodeficiencies Due to Miscellaneous Defects
Immunodeficiencies Resulting in Defective Homeostasis of the Immune System
Defects in the Cytolytic Pathway
Inherited Deficiency of the Complement System
Defects in Innate Immunity

Autoimmunity


Definitions and Types of Autoimmunity
Type II Autoimmune Reactions - Mechanisms of Autoimmune Tissue Injury and Examples
Type IIA Autoimmune Reaction: Autoimmune Hemolytic Anemia - Mechanisms of Autoimmune Tissue Injury and Examples
Type IIB Hypersensitivity: Gravesí Disease - Mechanisms of Autoimmune Tissue Injury and Examples
Type IIB Hypersensitivity: Myasthenia Gravis - Mechanisms of Autoimmune Tissue Injury and Examples
Type III Autoimmune Reactions (Immune Complex Disease) - Mechanisms of Autoimmune Tissue Injury
Type IV Autoimmune Reactions (T-Cell Mediated) - Mechanisms of Autoimmune Tissue Injury and Examples
Epidemiology of Autoimmune Disease
Animal Models of Autoimmune Disease
SLE (NZB X NZW F1, MRL, BXSB, TMPD)
Rheumatoid Arthritis (Collagen-Induced Arthritis, TTP Deficiency, K/BxN Model)
Multiple Sclerosis (Experimental Autoimmune Encephalomyelitis)
Type I Diabetes (Nonobese Diabetic Mouse Model)
Autoimmune Thyroiditis (Experimental Autoimmune Thyroiditis)
Pathogenesis of Autoimmune Disease
Treatment of Autoimmune Disease

Chronic Lymphocytic Leukemia


B-Cell Activation and Maturation
Characterizing the Heterogeneity of B-CLL by Molecular and Clinical Subtypes
Development of B-CLL From Normal B Lymphocytes
Correlations Between the Cellular and Molecular Features of the Disease With the Clinical Course of B-CLL
Summary Remarks on the Development, Growth, and Evolution of B-CLL
Animal Models of B-CLL
Clinical Implications and the Development of Novel Therapeutics

Immunology of HIV Infections


Immunological and Biological Parameters of Disease
Animal Models of HIV Infection
Vaccines to Prevent HIV Infection
Vaccine Candidates - Immunology of HIV Infections

Immunological Aspects of Allergy and Anaphylaxis


Immunological Aspects of Allergy and Anaphylaxis
Allergic Hypersensitivity
Atopy
Systemic Anaphylaxis and Anaphylactoid Reactions
Allergic Conjunctivitis
Allergic Disease of the Respiratory Tract
Allergic Rhinitis: Overview, Clinical Disease States, Experimental Models
Allergic Asthma: Overview, Immunology, Experimental Models
Food Allergy and Intolerance: Diagnosis, Food Intolerance
Skin Diseases and Allergy

Immunological Aspects of Skin Diseases


Immunological Aspects of Skin Diseases
Psoriasis - Skin Diseases
Alopecia Areata
Antibody Induced Bullous Skin Lesions

Experimental Approaches to the Study of Autoimmune Rheumatic Diseases


Experimental Approaches to the Study of Autoimmune Rheumatic Diseases
Types of Animal Models
Rheumatoid Arthritis: Etiology, Pathogenesis, Clinical Features, Treatment
Animal Models of Rheumatoid Arthritis
Systemic Lupus Erythematosus: Epidemiology, Etiology, Pathogenesis, Clinical Features, Treatment
Animal Models of Systemic Lupus Erythematosus(SLE)
Sjogrenís Syndrome: Epidemiology, Etiology, Pathogenesis, Clinical Features, Treatment, Animal Models
Progressive Systemic Sclerosis: Epidemiology, Etiology, Pathogenesis, Clinical Features, Treatment, Animal Models
Polymyositis: Epidemiology, Etiology, Pathogenesis, Clinical Features, Treatment, Animal Models
Seronegative Spondyloarthropathy: Epidemiology, Etiology, Pathogenesis, Clinical Features, Treatment, Animal Models

Immunological Aspects of Cardiac Disease


Rheumatic Fever
Epidemiology and Pathogenesis of Rheumatic Fever
Rheumatic Fever: Genetics
Etiologic Considerations of Rheumatic Fever
Animal Models of Rheumatic Fever
Streptococcal Vaccine Candidate
Chagasí Disease
Host-Parasite Interaction and Host Susceptibility of Chagasí Disease
Pathogenesis and Modulation of Immune Function - Chagasí Disease
Autoimmunity and Pathogenesis of Chagasí Disease
Molecular Mimicry in Chagasí Disease
Parasite-Directed Pathogenesis of Chagasí Disease
Myocarditis - Immune-Mediated Myocardial Diseases
Dilated Cardiomyopathy - Immune Mediated Myocardial Diseases

Immunological Aspects of Chest Diseases


Immunological Aspects of Chest Diseases: The Case of Tuberculosis
Epidemiology - Tuberculosis
TB and AIDS
Clinical Tuberculosis
Experimental Studies of Tuberculosis
The Mouse Model of Chronic Tuberculosis
Host-Pathogen Interactions in TB

Immunological Aspects of Gastrointestinal and Liver Disease


Mucosal Immunity
Pernicious Anemia - Immune Mediated Diseases of the Gastrointestinal Tract
Gluten Sensitive Enteropathy - Immune Mediated Diseases of the Gastrointestinal Tract
Inflammatory Bowel Disease - Immune Mediated Diseases of the Gastrointestinal Tract
Liver Immunology
Hepatitis B - Diseases of the Liver
Hepatitis C - Diseases of the Liver
Other Hepatitis Viruses - Diseases of the Liver
Primary Biliary Cirrhosis - Diseases of the Liver
Primary Sclerosing Cholangitis - Diseases of the Liver
Autoimmune Hepatitis - Diseases of the Liver

Immunological Aspects of Endocrine Disease


Insulin-Dependent Diabetes Mellitus
Animal Models of Insulin-Dependent Diabetes Mellitus
?-Cell Lesion: Nature of Effector Cells - Insulin Dependent Diabetes Mellitus
Rupture of Tolerance to ?-Cell Antigens - Insulin Dependent Diabetes Mellitus
Etiology of Insulin Dependent Diabetes Mellitus
Clinical Considerations of Insulin Dependent Diabetes Mellitus

Immune Mediated Neurological Syndromes


Multiple Sclerosis
Guillain-Barrť Syndrome
Myasthenia Gravis
Central Nervous System Systemic Lupus Erythematosus
Animal Models of Central Nervous System

Immunological Aspects of Renal Disease


Immunological Aspects of Renal Disease
Mechanisms of Immune Injury to the Kidneys
Specific Immune-Related Renal Diseases: IgA Nephropathy
Minimal Change Disease
Focal Sclerosing Glomerulosclerosis
Membranous Nephropathy
Membranoproliferative Glomerulonephritis
Rapidly Progressive Glomerulonephritis
Lupus Nephritis
Acute Poststreptococcal Glomerulonephritis
Mixed Cryoglobulinemia

Immunological Aspects of Transplantation


Immunological Aspects of Transplantation
Immunological Considerations of Transplantation
Laboratory Testing for Compatibility in Transplantation
Types of Solid Organ Allograft Rejection
Prevention and Management of Solid Organ Allograft Rejection
Solid Organ Transplantation Outcomes
Hematopoietic Stem Cell Transplantation



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