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Biochemical Pharmacology

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Biochemical Pharmacology


-:- What is `biochemical pharmacology'?
-:- What are drugs?
-:- Drugs and drug target molecules
-:- Drug molecules may or may not have physiological counterparts
-:- Synthetic drugs may exceed the corresponding physiological agonists in selectivity
-:- Metabolism of physiological mediators and of drugs
-:- Strategies of drug development
-:- Pharmacokinetics
-:- Drug application and uptake - Pharmacokinetics
-:- Drug distribution - Pharmacokinetics
-:- Drug elimination: Kidneys
-:- Drug elimination: Metabolism
-:- Pharmacodynamics
-:- Classes of drug receptors
-:- Mechanisms and kinetics of drug receptor interaction
-:- Drug dose-effect relationships in biochemical cascades
-:- Spare receptors
-:- Potency and efficacy
-:- Partial agonism and the two-state model of receptor activation
-:- Toxic and beneficial drug effects
-:- The ionic basis of cell excitation
-:- Ion gradients across the cell plasma membrane
-:- The physics of membrane potentials
-:- Voltage-gated cation channels and the action potential
-:- The origin of cell excitation
-:- Anion channels
-:- Drugs that act on sodium and potassium channels
-:- Local anesthetics
-:- Sodium channel blockers as antiarrhythmic agents
-:- Sodium channel blockers in epilepsia
-:- Potassium channel blockers
-:- Potassium channel openers
-:- Some aspects of calcium pharmacology
-:- Calcium in muscle cell function
-:- Calcium channel blockers
-:- Digitalis (foxglove) glycosides
-:- Calcium-dependent signaling by adrenergic receptors
-:- Some aspects of neurophysiology relevant to pharmacology
-:- Structure and function of synapses
-:- Mechanisms of drug action on synapses
-:- Pharmacologically important neurotransmitters and their receptors
-:- Neurotransmitter receptors
-:- Overview of the autonomic nervous system
-:- G protein-coupled receptors
-:- Structure and function of G protein-coupled receptors
-:- The complexity of G protein signalling
-:- Agonist-specific coupling
-:- GPCR oligomerization
-:- 'Allosteric' GPCR agonists and antagonists
-:- Pharmacology of cholinergic synapses
-:- Structure and function of the nicotinic acetylcholine receptor
-:- Cholinergic agonists
-:- Cholinergic antagonists
-:- Cholinesterase antagonists
-:- Pharmacology of catecholamines and of serotonin
-:- Biosynthesis and degradation of catecholamines
-:- Pharmacokinetic aspects
-:- Drug targets in catecholaminergic synapses
-:- Adrenergic receptor agonists and antagonists
-:- Inhibitors of presynaptic transmitter reuptake
-:- Inhibition of vesicular storage
-:- Indirect sympathomimetics
-:- L-DOPA and carbidopa in the therapy of Parkinson's disease
-:- False transmitters
-:- Cytotoxic catecholamine analogs
-:- Monoamine oxidase inhibitors
-:- Pharmacology of nitric oxide (NO)
-:- Vascular effects of nitric oxide
-:- Nitric oxide synthase and its isoforms
-:- Biochemical mechanisms of NO signaling
-:- Role of NO in macrophages
-:- NO releasing drugs
-:- NOS inhibitors
-:- Pharmacology of Eicosanoids
-:- Biosynthesis of eicosanoids
-:- Cyclooxygenase inhibitors
-:- Lipoxygenases and related drugs
-:- Some principles of cancer pharmacotherapy
-:- Cell type-specific antitumor drugs
-:- The cell cycle
-:- Alkylating agents
-:- Antibiotics
-:- Antimetabolites
-:- Inhibitors of mitosis
-:- Monoclonal antibodies in tumour therapy