Biochemical Pharmacology

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Biochemical Pharmacology


=> What is `biochemical pharmacology'?
=> What are drugs?
=> Drugs and drug target molecules
=> Drug molecules may or may not have physiological counterparts
=> Synthetic drugs may exceed the corresponding physiological agonists in selectivity
=> Metabolism of physiological mediators and of drugs
=> Strategies of drug development


=> Pharmacokinetics
=> Drug application and uptake - Pharmacokinetics
=> Drug distribution - Pharmacokinetics
=> Drug elimination: Kidneys
=> Drug elimination: Metabolism


=> Pharmacodynamics
=> Classes of drug receptors
=> Mechanisms and kinetics of drug receptor interaction
=> Drug dose-effect relationships in biochemical cascades
=> Spare receptors
=> Potency and efficacy
=> Partial agonism and the two-state model of receptor activation
=> Toxic and beneficial drug effects

The ionic basis of cell excitation

=> The ionic basis of cell excitation
=> Ion gradients across the cell plasma membrane
=> The physics of membrane potentials
=> Voltage-gated cation channels and the action potential
=> The origin of cell excitation
=> Anion channels

Drugs that act on sodium and potassium channels

=> Drugs that act on sodium and potassium channels
=> Local anesthetics
=> Sodium channel blockers as antiarrhythmic agents
=> Sodium channel blockers in epilepsia
=> Potassium channel blockers
=> Potassium channel openers

Some aspects of calcium pharmacology

=> Some aspects of calcium pharmacology
=> Calcium in muscle cell function
=> Calcium channel blockers
=> Digitalis (foxglove) glycosides
=> Calcium-dependent signaling by adrenergic receptors

Some aspects of neurophysiology relevant to pharmacology

=> Some aspects of neurophysiology relevant to pharmacology
=> Structure and function of synapses
=> Mechanisms of drug action on synapses
=> Pharmacologically important neurotransmitters and their receptors
=> Neurotransmitter receptors
=> Overview of the autonomic nervous system

G protein coupled receptors

=> G protein-coupled receptors
=> Structure and function of G protein-coupled receptors
=> The complexity of G protein signalling
=> Agonist-specific coupling
=> GPCR oligomerization
=> 'Allosteric' GPCR agonists and antagonists

Pharmacology of cholinergic synapses

=> Pharmacology of cholinergic synapses
=> Structure and function of the nicotinic acetylcholine receptor
=> Cholinergic agonists
=> Cholinergic antagonists
=> Cholinesterase antagonists

Pharmacology of catecholamines and of serotonin

=> Pharmacology of catecholamines and of serotonin
=> Biosynthesis and degradation of catecholamines
=> Pharmacokinetic aspects
=> Drug targets in catecholaminergic synapses
=> Adrenergic receptor agonists and antagonists
=> Inhibitors of presynaptic transmitter reuptake
=> Inhibition of vesicular storage
=> Indirect sympathomimetics
=> L-DOPA and carbidopa in the therapy of Parkinson's disease
=> False transmitters
=> Cytotoxic catecholamine analogs
=> Monoamine oxidase inhibitors

Pharmacology of nitric oxide NO

=> Pharmacology of nitric oxide (NO)
=> Vascular effects of nitric oxide
=> Nitric oxide synthase and its isoforms
=> Biochemical mechanisms of NO signaling
=> Role of NO in macrophages
=> NO releasing drugs
=> NOS inhibitors

Pharmacology of Eicosanoids

=> Pharmacology of Eicosanoids
=> Biosynthesis of eicosanoids
=> Cyclooxygenase inhibitors
=> Lipoxygenases and related drugs

Some principles of cancer pharmacotherapy

=> Some principles of cancer pharmacotherapy
=> Cell type-specific antitumor drugs
=> The cell cycle
=> Alkylating agents
=> Antibiotics
=> Antimetabolites
=> Inhibitors of mitosis
=> Monoclonal antibodies in tumour therapy

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