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Chapter: Biochemical Pharmacology : Some principles of cancer pharmacotherapy

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The cell cycle

General cytotoxic drugs may be classified according to their relationship to the cell cycle (Figure 13.6).

The cell cycle

General cytotoxic drugs may be classified according to their relationship to the cell cycle (Figure 13.6). Cell cycle-spe-cific agents may affect either the S phase (i.e., DNA syn-thesis) or the M phase (i.e., mitosis). Cell cycle-nonselective agents may damage the cell throughout the cycle, mostly by direct chemical modification of the DNA.



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