When compared with gas chromatography, HPLC has only a few differences in the scale of operation; accuracy; precision; sensitivity; selectivity; and time, cost, and equipment necessary. Injection volumes in HPLC are usually significantly larger than in GC because of the greater capacity of HPLC columns. Precision in HPLC is often better due to the routine use of loop injectors. Because HPLC is not limited to volatile analytes, the range of compounds that can be analyzed is somewhat larger than for GC. Capillary GC columns, on the other hand, have more theoretical plates, providing greater resolving power for complex mixtures.
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