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Chapter: Microbiology

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Characterization of antibodies

Early physical – chemical studies were done with Ig G from horse, rabbit and human

Characterization of antibodies

·     Early physical – chemical studies were done with Ig G from horse, rabbit and human

 

·     Important structural features were predicted even before sophisti-cated studies were available

 

·     Molecular weight was calculated from sedimentation and diffusion studies

 

·     Asymmetrical and or non globular form by viscosity studies

 

·     Globular domain structure from unique susceptibility to proteolytic enzymes

 

·     Two antigen binding sites by hapten antibody reactions

 

·     Thus early studies predicted three functional domains and have been confirmed

 

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