Summary
Respiration
is a biological process in which energy is released by breaking down of complex
organic substances into simple compounds. The respiratory substrates may be
carbohydrate, protein or fats. Respiration is of two types, aerobic (with O2)
and anaerobic (without O2). All plants, animals and most of the
microbes derive energy from aerobic respiration. Some bacteria and fungi like
yeast show anaerobic respiration. Aerobic respiration consists of four stages
and they are glycolysis, link reaction, TCA cycle and ETS. Glycolysis is the
first stage which occurs in cytosol and common for both aerobic and anaerobic
respiration and it involves breaking down of glucose into two molecules of
pyruvic acid. Acetyl CoA formed from pyruvic acid, acts as a link between
glycolysis and Krebs cycle. Krebs cycle takes place in matrix of mitochondria
and also called as citric acid cycle in which CO2 and H2O
were produced. Hydrogen removed from the substrates is received by coenzymes
which get reduced. They are again oxidised by removal of hydrogen. This
hydrogen splits into protons and electrons. The electrons transferred through
various electron transport carriers present in inner membrane of mitochondria
is used for the synthesis of ATP with the help of ATP synthase. This process is
called oxidative phosphorylation.
Anaerobic
respiration involves incomplete breaking down of the substrate glucose into
ethyl alcohol or lactic acid. In aerobic respiration 36 ATP molecules are
produced in plant mitochondria but in animals 38 ATP molecules are produced per
glucose molecule. During anaerobic respiration only 2 ATP molecules are
produced, therefore anaerobic respiration is less efficient than aerobic
respiration. The respiratory quotient (RQ) is the ratio of carbon dioxide
production to oxygen consumption and reflects the relative contributions of
fat, carbohydrate, and protein to the oxidation. Pentose phosphate pathway is
an alternative pathway to glycolysis and TCA cycle for oxidation of glucose. It
occurs in cytoplasm of both prokaryotes and eukaryotes.
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