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Chapter: Introduction to Human Nutrition: The Vitamins

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Metabolic functions of vitamin B6

Pyridoxal phosphate is a coenzyme in three main areas of metabolism:

Metabolic functions of vitamin B6


Pyridoxal phosphate is a coenzyme in three main areas of metabolism:


      in a wide variety of reactions of amino acids, espe-cially transamination, in which it functions as the intermediate carrier of the amino group, and decar-boxylation to form amines

 

      as the cofactor of glycogen phosphorylase in muscle and liver, where it is the phosphate group that is catalytically important

 

      in the regulation of the action of steroid hormones. Pyridoxal phosphate acts to remove the hormone–receptor complex from DNA binding, and so ter-minate the action of the hormones. In vitamin B6 deficiency there is increased sensitivity and respon-siveness of target tissues to low concentrations of steroid hormones, including estrogens, androgens, cortisol, and vitamin D.


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