Autospecificity - Antigen

Autospecificity

Self-antigens are generally nonantigenic. Sequestrated antigens (such as eye lens protein and sperm) are, however, exceptions, because these are not recognized as self-antigens. This is because corneal tissue and sperm are never encountered by the immune system during the development of tolerance to self-antigens. Therefore, these tissues become immunogenic if accidentally or experimentally released into the blood or tissues.