Chemical Coordination and Integration
Answer the following questions
14. Comment on homeostasis
• Maintenance of constant internal environment
of the body by different co-ordinating system.
• The maintenance of constant internal
environment of the body is due to the functioning of endocrine system and nervous
a) If the calcium level in the blood decreases the parathyroid gland secrete parathyroid
hormones and increases calcium level in the blood.
b) If there is more calcium in the blood the other
hormone secreted by parathyroid gland called calcitonin acts against the parathormone
and reduces calcium level.
a) The adrenalin secreted by adrenal gland in emergency increases heart beat rate
and blood pressure.
The other hormone secreted by adrenal is nor-adrenalin which reduces heart beat
rate and blood pressure.
a) The sympathetic nervous system at the time of shock induces tear glands to secrete
The parasympathetic nerve at the time of shock and emotion reduces the tear secretion.
15. Hormones are known as chemical messenger. Justify.
• Hormones are chemical messengers,
because they acts as organic catalysts and co-enzymes to perform specific functions
in the target organs.
16. Write the role of oestrogen in ovulation.
Oestrogen hormones promotes the growth of ovarian follicle
While the follicles are growing it secretes the hormone oestrogen which in turn
promotes the ovum to develop.
The shedding up of ovum at the Luteal phase takes place by the influence of Leutenizing
17. Comment on Acini of thyroid gland.
The thyroid gland is a bilobed gland. Each lobe is made up of many lobules.
The lobules consists of follicles called acinus. Each acinus is lined with glandular
cuboidal or squamous epithelial cells.
The lumen of acinus is filled with colloid which contains thyro globulin molecules.
18. Write the causes for diabetes mellitus and diabetes insipidus.
• Diabetes metitus: If the insulin is not secreted sufficiently
the liver and muscles are unable to convert the glucose into glycogen. As a result
more glucose enters in to the blood stream raising the blood sugar level leads to
• Diabetes Insipidus: The hormone anti diuretic hormone
is secreted by the neuro hypophysis, which promotes re absorption of water and thus
reduces the loss of water through urine ADH deficiency induces the production of
large amount of urine leads to diabetes insipidus.
19. Specify the symptoms of acromegaly
• Acromegaly is due to excessive secretion
of growth hormone in adults. The symptoms are over growth of hand bones, feet bones,
Jaw bones malfunctioning of gonads enlargement of Viscera. Tongue, lungs, heart,
liver spleen, thyroid and adrenal gland.
20. Write the symptoms of cretinism.
• Decreased secretion of thyroid (Hypothyroidism)
causes cretinism. The cretins shows retarded skeletal growth, absence of sexual
maturity retarded mental ability thick wrinkled skin, protruded enlarged tongue
bloated face, thick and short limbs occurs. The other symptoms are low BMR slow
pulse rate, sub normal body temperature and elevated blood cholestero level.
21. Briefly explain the structure of thyroid gland.
It is the largest endocrine gland.
Thyroid gland is a butterfly shaped bi-lobed gland located below the larynx on each
side of upper trachea.
The two lateral lobes are connected by a median tissue mass called isthmus.
Each lobe is made up of many lobules.
The lobules consists of follicles called acini.
Each aninus is lined with glandular cuboidal squamous epithelial cells.
The lumen of acinus is filled with colloid a thick glycoprotein mixture consisting
of thyroglobulin molecules.
22. Name the layers of adrenal cortex and mention their secretions.
• The adrenal cortex has three layers
namely Zona glomerulosa, Zona fasciculate and Zona reticulate. Zona glomerulosa
which constitutes 15% of cortex is a thin outer layer secretes minerals corticoids
• Zona fasciculate the middle widest
layer constitutes 75% cortex and secretes gluco corticosteroids such as cortisol,
corticosterone and small amount of adrenal androgen and oestrogen.
• Zona reticulata an inner layer of
about 19% of cortex and secretes adrenal androgen and small amount of estrogen and
23. Differentiate hyperglycemia from hypoglycemia.
is condition in which there is increased blood glucose level, it may be due to the
reduced secretion of insulin.
is a condition in which the blood glucose level decreases. It may be due to increased
secretion of insulin there by reducing blood glucose level.
24 Write the functions of (CCK) Cholecystokinin.
• Cholecystokinin (CCK) is secreted
by duodenum in response to the presence of fat and acid in the diet. It acts on
the gall bladder to release bile into duodenum and stimulates the secretion of pancreatic
enzymes and its discharge
25. Growth hormone is important for normal growth. Justify the statement.
hormone promotes growth of all the tissues and metabolic process of the cell. The
growth hormone stimulates the growth in the following ways
It influences the metabolism of carbohydrate proteins and lipids.
It increases the rate of protein biosynthesis.
It stimulates cartilage formation of condrogenesis.
It stimulates bone formation osteogenesis.
It helps in the retention of minerals like nitrogen, potassium, phosphorous sodium
in the body.
It increases the release of fatty acid from adipose tissue.
It decreases the rate of glucose utilization for energy by the cell, by which it
conserves glucose for glucose dependent tissues such as the brain.
26. Pineal gland is an endocrine gland, write its role.
• As pineal gland secretes hormone melotonin
it is an endocrine gland.
• Melotonin hormone plays a central
role in the regulation of circadian rhythm of our body and maintains the normal
sleep wake cycle.
• It also regulates the timing of sexual
maturation of gonads.
• Melatonin also influences metabolism
pigmentation menstrual cycle and defence mechanism of our body.
27. Comment on the functions of adrenalin.
Adrenalin increases liver glycogen breakdown into glucose and increases the release
of fatty acids from fat cells.
During emergency it increases heart beat rate and blood pressure.
It stimulates the smooth muscles of cutaneous and visceral arteries to decrease
It increases blood flow to the skeletal muscles there by increases the metabolic
rate of skeletal muscles cardiac muscles and nervous tissues.
28. Predict the effects of removal of pancreas from the human body.
• Surgical removal of pancreas is due
to some clinical reasons is known as pancreatectomy.
• The following are the effect of pancreatectomy.
There may be hypoglycemic and hyperglycomic manifestation. As there is a complete
absence of endogenous insulin and glycogen leads to pancreatic diabetic mellitus.
There may be anastomatic ulcer.
• There may be low level of fat souble
• There may be weight loss
• There may be chronic diarrohea
• There may be loss of appetite
• There may be fatiqueness and vomiting,
Elevated cholesterol level
• There may be poor life expectancy.
• There may be physical emotional cognitive
and social functional declining.
29. Enumerate the role of kidney as an endocrine gland.
• Kidney is a partial endocrine gland.
Kidney secretes hormones such as renin, erythropoietin and calcitriol.
• Renin is secreted by Juxta glomerular
cells (JGA) which increase blood pressure when angiotensin is formed in blood.
• Erythropoietin is also secreted by
JGA cells of the kidney and stimulates the formation of RBC in bone marrow known
• Calcitriol is secreated by proximal
tubules of nephron, it is an active form of vitamin D3 which promotes calcium and
phosphorus absorption from intestine and accelerates bone formation.
30. Write a detailed account of gastro intestinal tract hormones.
• These are specialized endocrine cells
present in gastro-intestinal tract secretes hormones such as gastrin cholecystokinin
secretin and gastric inhibitory peptides.
• Gastrin acts on the gastric glands
and stimulates the secretion of HC1 and Pepsinogen.
• Cholecystokinin is secreted by duodenum
in response to the presence of fat and acid in the diet.
• It acts on the gall bladder to release
in to duodenum and stimulates the secretion of pancreatic enzymes and its discharge.
• Secretion acts on acini cells of pancreas
to secrete bicarbonate ions and water to neutralize the acidity.
• Gastric inhibitory peptide (GIP) inhibits,
gastric secretion and motility.