Acebutolol (Sectral) is a cardioselective β1-adrenocep-tor blocking agent that also has some minor membrane stabilizing effects on the action potential.
Acebutolol’s effects on the atria, sinoatrial and AV nodes, His-Purkinje system, and ventricular muscle are similar to those of propranolol.
Acebutolol reduces blood pressure in patients with es-sential hypertension primarily through its negative ino-tropic and chronotropic effects.
The pharmacokinetic characteristics of acebutolol:
Oral bioavailability : 70%
Onset of action : 1–3 hours
Peak response : 3–8 hours
Duration of action : 12–24 hours
Plasma half-life : 3–4 hours
Primary route of metabolism: Hepatic
Primary route of excretion : Renal (30–40%); biliary/fecal (50–60%)
Therapeutic serum concentration: Not established
Acebutolol is effective in the management of the patient with essential hypertension, angina pectoris, and ventric-ular arrhythmias. Antiarrhythmic effects are observed with the patient both at rest and taking exercise.
Adverse effects include bradycardia, gastrointestinal upset, dizziness, and headache.
Acebutolol should not be administered in cardiogenic shock, uncontrolled heart failure, or severe bradycar-dia or to patients with known hypersensitivity to the drug.
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