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Chapter: Modern Medical Toxicology: Miscellaneous Drugs and Poisons: Gastrointestinal and Endocrinal Drugs

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Immunostimulants

1. Natural adjuvants : Bacillus Calmette-Guerin (BCG),immune globulin. 2. Synthetic agents : Levamisole, cytokines.

Immunostimulants

Classification

·      Natural adjuvants : Bacillus Calmette-Guerin (BCG),immune globulin.

·              Synthetic agents : Levamisole, cytokines.

Uses

Treatment of

■■  Immunodeficiency disorders, (e.g. AIDS).

■■  Chronic infectious diseases.

■■  Cancer.

Clinical (Toxic) Features

·      BCG: Hypersensitivity, shock, fever, immune complexdisease.

·      Immune globulin: Allergic reactions.

·              Cytokines: Hypotension, CVS toxicity, pulmonary oedema,renal toxicity, bone marrow suppression, CNS toxicity.

 

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