Immunostimulants

Immunostimulants

Classification

·      Natural adjuvants : Bacillus Calmette-Guerin (BCG),immune globulin.

·              Synthetic agents : Levamisole, cytokines.

Uses

Treatment of

■■  Immunodeficiency disorders, (e.g. AIDS).

■■  Chronic infectious diseases.

■■  Cancer.

Clinical (Toxic) Features

·      BCG: Hypersensitivity, shock, fever, immune complexdisease.

·      Immune globulin: Allergic reactions.

·              Cytokines: Hypotension, CVS toxicity, pulmonary oedema,renal toxicity, bone marrow suppression, CNS toxicity.