Hydronephrosis - Kidney Disease

Hydronephrosis

·        Dilation of renal pelvis due to:

o   Obstruction of the pelvo-ureteric junction (often in kids)

o   Big prostates

o   Kidney stones

·        Leads to renal failure due to:

o   Chronic interstitial nephritis (as do other things): leucocyte invasion. 

o   Atrophy of the collecting ducts and distal tubule (which are relatively hypoxic compared to the glomerulus). However, if the tubule goes, the glomeruli scleroses Þ loose whole nephron