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Chapter: Ophthalmology: Optic Nerve

Arteritic Anterior Ischemic Optic Neuropathy

An acute disruption of the blood supply to the optic disk due to inflammation of medium-sized and small arterial branches.

Arteritic Anterior Ischemic Optic Neuropathy

Definition

An acute disruption of the blood supply to the optic disk due to inflammation of medium-sized and small arterial branches.

Epidemiology:

The annual incidence is approximately three cases per100000. The disorder occurs almost exclusively after the age of 60. Women are affected slightly more often than men, accounting for 55% of all cases. Fifty per cent of all patients suffer from ocular involvement within a few days up to approximately three months of the onset of the disorder.

Etiology:

Giant cell arteritis is a frequently bilateral granulomatous vasculitisthat primarily affects the medium-sized and small arteries. Common sites include the temporal arteries, ophthalmic artery, short posterior ciliary arter-ies, central retinal artery, and the proximal portion of the vertebral arteries, which may be affected in varying combinations.

Symptoms:

Patients reportsudden unilateral blindness or severe visualimpairment. Other symptoms include headaches, painful scalp in the regionof the temporal arteries, tenderness to palpation in the region of the temporal arteries, pain while chewing (a characteristic sign), weight loss, reduced general health and exercise tolerance. Patients may have a history of amauro-sis fugax or polymyalgia rheumatica.

Diagnostic considerations:

The ophthalmoscopic findings are the same asin arteriosclerotic AION (see Fig. 13.12a). Other findings include a signifi-cantly increased erythrocyte sedimentation rate (precipitous sedimentation is the most important hematologic finding), an increased level of C-reactive protein, leukocytosis, and iron-deficiency anemia.


Erythrocyte sedimentation rate should be measured in every patient presenting with anterior ischemic optic neuropathy.

The temporal arteries are prominent (Fig. 13.13), painful to palpation, and have no pulse. The diagnosis is confirmed by a biopsy of the temporal artery. Because of the segmental pattern of vascular involvement, negative histologic findings cannot exclude giant cell arteritis.


Giant cell arteritis should be considered in every patient presenting with anterior ischemic optic neuropathy.

Differential diagnosis:

Arteriosclerotic AION should be considered.

Treatment:

Immediatehigh-dosage systemic steroid therapy (initial doses upto 1000 mg of intravenous prednisone) is indicated. Steroids are reduced as the erythrocyte sedimentation rate decreases, C-reactive protein levels drop, and clinical symptoms abate. However, a maintenance dose will be required for several months. Vascular treatment such as pentoxifylline infusions may be attempted.

High-dosage systemic steroid therapy (for example 250 mg of intravenous prednisone) is indicated to protect the fellow eye even if a giant cell arteritis is only suspected.

Prognosis:

The prognosis for the affected eye ispooreven where therapy isinitiated early. Immediate steroid therapy is absolutely indicated because in approximately 75% of all cases the fellow eye is affected within a few hours and cerebral arteries may also be at risk.

 

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