Membranes in Drug Delivery
Because
the driving force behind the formation of lipid bilayers is the exclusion of
water from the hydrophobic region of lipids, and not some enzymatic process,
artificial membranes can be created in the lab. Liposomes are stable structures based on a lipid bilayer that form
a spherical vesicle. These vesicles can be prepared with therapeutic agents on
the inside and then used to deliver the agent to a target tissue.
Every
year, more than a million Americans are diagnosed with skin cancer, most often
caused by long-term exposure to ultravio-let light. The ultraviolet (UV) light
damages DNA in several ways, with one of the most common being the production
of dimers between two pyrimidine bases. For a species with little body hair and
a fondness for sunshine, humans are poorly equipped to fight damaged DNA in
their skin. Of the 130 known human DNA-repair enzymes, only one system is
designed to repair the main DNA lesions caused by exposure to UV. Several lower
species have repair enzymes that we lack.
Researchers
have developed a skin lotion to counteract the effects of UV light. The lotion
contains liposomes filled with a DNA-repair enzyme from a virus, called T4
endonuclease V. The liposomes penetrate the skin cells. Once inside, the
enzymes make their way to the nucleus, where they attack pyrimidine dimers and
start a DNA-repair mechanism that the normal cel-lular processes can complete.
The skin lotion, marketed by AGIDermatics, is currently undergoing clinical
trials. Check out the AGI Dermatics website (http:// www. agiderm.com) for informa-tion on the results of the
clinical trials.
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