Home | | Introduction to Human Nutrition | Trans fatty acids - Effect of diet on serum lipids and lipoproteins

Chapter: Introduction to Human Nutrition: Nutrition and Metabolism of Lipids

Trans fatty acids - Effect of diet on serum lipids and lipoproteins

While saturated fats consist of straight chains of carbon atoms which pack together tightly in the phospholipids of cell membranes and lipoproteins.

Trans fatty acids

While saturated fats consist of straight chains of carbon atoms which pack together tightly in the phospholipids of cell membranes and lipoproteins, in contrast, carbon double bonds in the cis configura-tion in MUFAs and PUFAs introduce a bend or kink into the carbon chain. This alters the physical proper-ties of the phospholipids containing these fatty acids, by, for example, increasing their packing volume, a physical property that contributes to an increase in membrane fluidity. The partial hydrogenation of MUFAs and PUFAs, most notably during the indus-trial processing of foods for the purpose of solidifying unsaturated oils, results in a loss of this kink as the fatty acid assumes a straighter, trans configuration that resembles that found in SFAs. This likeness in chemical structure is thought to account for the SFA-like effects of trans fatty acids such as elaidic acid (trans isomer of oleic acid) on serum lipids (see Figures 6.1 and 6.2). The results of prospective cohort studies such as the Nurses’ Health Study showed that high levels of trans fats in excess of 7% energy increased serum LDLs and reduced HDLs (Willet et al. 1993). However, despite the continued use of par-tially hydrogenated fats in food products, the average intake of trans fatty acids in most Western diets does not exceed 2% of total energy intake, and at this level of intake these fats are unlikely to exert adverse effects on serum lipoproteins.



Figure 6.1 Stick models illustrating the basic structural differences between saturated, cis-monounsaturated, and cis-polyunsaturated fatty acids. As shown in two dimensions, the increasing curvature caused by inserting one or more double bonds increases the area occupied by the fatty acid. The physical area occupied by unsaturated fatty acids is further accentuated in three dimensions because esteri-fied fatty acids rotate around the anchored terminal.



Figure 6.2 Stick models comparing a cis- with a trans-unsaturated fatty acid. A cis-unsaturated double bond creates a U-shaped space and confers curvature to the molecule because, relative to the longi-tudinal axis of the fatty acid, the two hydrogens at the double bond are on the same side of the molecule. A trans-unsaturated double bond does not confer curvature to the molecule because the hydrogens are on opposite sides of the double bond. A trans-double bond therefore tends to give the fatty acid physicochemical properties more like that of a saturated fatty acid.


Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail
Introduction to Human Nutrition: Nutrition and Metabolism of Lipids : Trans fatty acids - Effect of diet on serum lipids and lipoproteins |


Privacy Policy, Terms and Conditions, DMCA Policy and Compliant

Copyright © 2018-2023 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.