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Chapter: Introduction to Human Nutrition: Nutrition and Metabolism of Lipids

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Postprandial lipemia

The turbidity or milkiness of serum or plasma follow-ing the ingestion of fat marks the arrival of dietary fat now contained in chylomicrons in the blood.

Postprandial lipemia

The turbidity or milkiness of serum or plasma follow-ing the ingestion of fat marks the arrival of dietary fat now contained in chylomicrons in the blood. The milky appearance of plasma or serum after the inges-tion of fat arises from the chylomicrons, which are of a sufficient size physically to scatter light and create the milky appearance of serum or plasma after a meal. The size and composition of the chylomicrons pro-duced after a fatty meal are determined by the fat content of the meal. Hence, the nature of fatty acids in chylomicron TAG reflects the nature of fatty acid in the meal. Each chylomicron particle carries a single molecule of apoB-48 which, unlike its other smaller counterparts A-I and A-IV, remains with the chylomi-cron throughout its life in the circulation. There is little evidence to suggest that the production of apoB-48, and thus the number of particles, increases in response to an increased flux of dietary fat. Instead, the enterocyte incorporates more TAG into each chy-lomicron and expands the size of each chylomicron to facilitate the transport of larger amounts of absorbed dietary fat. There is evidence to suggest that chylomicrons containing lipids enriched with poly-unsaturated fatty acids (PUFAs) are larger than chylomicrons enriched with saturated fat, since the former occupy more space when packaged into a lipo-protein. This has implications for the subsequent metabolism and fate of these lipoproteins in the cir-culation, since TAGs associated with larger chylomi-crons are known to be hydrolyzed more rapidly. It is thought that apoB-48 is produced continuously in the enterocyte-forming pools of apoB-48 in readiness for the sudden reception of dietary fat and production of chylomicrons. Nevertheless, small chylomicrons can be detected throughout the postabsorptive phase.

 

The onset, duration, and magnitude of postpran-dial lipemia can be monitored in the laboratory after a standard fat-containing meal by making serial mea-surements of serum TAG or more specifically TAG associated with TAG-rich lipoproteins over a post-prandial period of up to 8 or 9 hours (remnants of chylomicrons can be detected 12 hours after a meal). Alternatively, the levels of apoB-48 or retinyl esters in serum act as useful markers or tracer molecules for following the metabolism of chylomicrons in the postprandial period. In normal subjects postpran-dial lipemia peaks between 3 and 4 hours and sub-sides to baseline concentration after 5–6 hours. In some cases, postprandial TAG (mainly in chylomi-crons) can appear in the blood within 30 min and peak as early as 1 hour after the ingestion of fat. So rapid is this rise in TAG that it is believed to represent preformed lipid in the enterocyte from the previous meal that is shunted into the circulation by the incom-ing fat load. Note that, in addition to the time taken to emulsify, hydrolyze, and absorb dietary fat, re-esterification of TAG in the enterocyte and lipopro-tein assembly alone takes about 15 min, although shunting means that the first TAG can appear within 30 min, with the first peak after 1 hour. This shunting phenomenon is particularly noticeable during the day and gives rise to two or even more peaks, whereas postprandial peaks following an overnight fast are usually monophasic.

Chylomicrons are not the only TAG-rich lipopro-teins in the postprandial phase. Chylomicrons clearly contribute significantly to the extent of postprandial lipemia, and the rate at which the TAGs in these lipo-proteins are hydrolyzed is known to be a critical deter-minant of the extent and time-course of postprandial lipemia. The TAGs in circulating chylomicrons are




lipolyzed by a rate-limiting lipase known as lipopro-tein lipase (LPL). LPL is tethered to the endothelial lining of blood vessels in peripheral tissues, most notably muscle and adipose tissue, by proteoglycan fibers, and as such is known as an endothelial lipase. Several molecules of LPL can interact and lipolyze the TAG from a single chylomicron particle to generate a chylomicron remnant which is removed by specific cell membrane receptors in the liver. The situation is com-plicated by the fact that TAG-rich lipoproteins from the liver, known as very low-density lipoprotein (VLDL), also contribute to this postprandial lipemia to variable extents in health and disease states. These VLDLs containing endogenously produced TAG are similar in lipid composition to chylomicrons but con-siderably smaller (Table 6.4). While chylomicrons carry up to 80% of measurable plasma TAG during the postprandial period, VLDL particles can carry up to 80% of the measurable protein (mainly as apo-B), and significantly outnumber chylomicrons at all times. VLDL-TAG are also metabolized by LPL, which creates competition for the clearance of endogenously and exogenously derived TAG carried by VLDLs and chy-lomicrons respectively.

 

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