Sertoli cell tumour - Genitourinary oncology

Sertoli-cell tumour

Definition

This is a non-germ-cell tumour of the testis, derived from the Sertoli cells which are part of the seminiferous tubules (sex cords). Also called androblastoma.

Incidence/prevalence

Less common than germ-cell tumours.

Age

Any. Peak at 40 years.

Sex

Male only

Aetiology

As for all testicular tumours.

Pathophysiology

The Sertoli cells form the testicular tubules and when stimulated by follicle-stimulating hormone from puberty, they are capable of supporting the maturation of spermatogonia. Normally they do not secrete sex hormones, but tumour cells may secrete low levels of androgens or oestrogens, but these are very rarely high enough to cause systemic effects. About 90% are benign.

Clinical features

As for testicular tumours.

Macroscopy/microscopy

Homogeneous grey-white to yellow masses of variable size, which are well circumscribed. Normal Sertoli-like cells with tall columnar cytoplasm, often forming cords like seminiferous tubules. Certain histological features predict metastasis; for example multiple mitoses and large cell calcifying cell type.

Complications, investigations, treatment

As for testicular tumours.