Home | | Medicine and surgery: Principles and practice of medicine and surgery | Sertoli cell tumour - Genitourinary oncology

Chapter: Medicine and surgery: Genitourinary system

Sertoli cell tumour - Genitourinary oncology

This is a non-germ-cell tumour of the testis, derived from the Sertoli cells which are part of the seminiferous tubules (sex cords). Also called androblastoma. - Definition, Incidence, Age, Sex, Aetiology, Pathophysiology, Clinical features, Complications, Investigations, Management, Prognosis.

Sertoli-cell tumour

 

Definition

 

This is a non-germ-cell tumour of the testis, derived from the Sertoli cells which are part of the seminiferous tubules (sex cords). Also called androblastoma.

 

Incidence/prevalence

 

Less common than germ-cell tumours.

 

Age

 

Any. Peak at 40 years.

 

Sex

 

Male only

 

Aetiology

 

As for all testicular tumours.


Pathophysiology

 

The Sertoli cells form the testicular tubules and when stimulated by follicle-stimulating hormone from puberty, they are capable of supporting the maturation of spermatogonia. Normally they do not secrete sex hormones, but tumour cells may secrete low levels of androgens or oestrogens, but these are very rarely high enough to cause systemic effects. About 90% are benign.

 

Clinical features

 

As for testicular tumours.

 

Macroscopy/microscopy

 

Homogeneous grey-white to yellow masses of variable size, which are well circumscribed. Normal Sertoli-like cells with tall columnar cytoplasm, often forming cords like seminiferous tubules. Certain histological features predict metastasis; for example multiple mitoses and large cell calcifying cell type.

 

Complications, investigations, treatment

 

As for testicular tumours.

Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail
Medicine and surgery: Genitourinary system : Sertoli cell tumour - Genitourinary oncology |


Privacy Policy, Terms and Conditions, DMCA Policy and Compliant

Copyright © 2018-2023 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.