Home | | Medicine Study Notes | Pancytopenia - Anaemias

Chapter: Medicine Study Notes : Haematology and Immunology

Pancytopenia - Anaemias

Stem Cells : Blood stem cells detected by CD34+

Pancytopenia

 

Stem Cells

 

·        Blood stem cells detected by CD34+

 

·        Live in bone marrow: biochemical environment there necessary for survival – from fat, fibroblasts, endothelial & macrophage cells

 

Pancytopenia

 

·        Confirmed ¯RBC, ¯WBC and ¯platelets

·        Causes: 

o  ¯Production:

§  Bone marrow infiltration/failure

§  Megaloblastic anaemia

§  Miscellaneous (e.g. alcohol)

§  Aplastic/hypoplastic anaemia 

o  ­Margination: Hypersplenism

 

Aplastic Anaemia

 

·        Rare

·        Defect in supportive environment: dysfunctional stem cells, autoimmune damage

·        Criteria for severe:

o  Neutrophils < 0.5

o  Platelets < 20

o  Reticulocytes < 10 * 10E9

o  Hypocellular marrow

·        Causes:

o  Idiopathic

o  Drugs/chemicals

o  Radiation

o  Viral

o  Pregnancy

·        Treatment:

o  Supportive care

o  Immunosuppressive treatment

o  Stem cell transplantation

 

Study Material, Lecturing Notes, Assignment, Reference, Wiki description explanation, brief detail
Medicine Study Notes : Haematology and Immunology : Pancytopenia - Anaemias |


Privacy Policy, Terms and Conditions, DMCA Policy and Compliant

Copyright © 2018-2024 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.