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Chapter: Medicine Study Notes : Haematology and Immunology

Myeloproliferative Disorders (MPD)

4 types: o Polycythaemia rubra vera o Essential thrombocythaemia o Myelofibrosis o Chronic granulocytic leukaemia (=chronic myeloid leukaemia)

Myeloproliferative Disorders (MPD)




·        Myelo = marrow

·        4 types:

o   Polycythaemia rubra vera

o   Essential thrombocythaemia

o   Myelofibrosis

o   Chronic granulocytic leukaemia (=chronic myeloid leukaemia) 

·        Primary, clonal proliferation of myeloid (marrow) cells

·        Arises at pluripotent stem cell level:

·        Leads to mixed picture as diseases merge

·        Variation is based on degree and type of proliferation: 

·        Leucoerythroblastosis:

o   Nucleated RBC and immature neutrophils in blood

o   Disturbance of blood/marrow barrier (normally stops immature cells getting out)

o   Causes:

§  Immature barrier: common in new born

§  Toxic: septicaemia

§  Hypoxia: respiratory failure 

§  ­­Marrow function

§  Mechanical damage: e.g. infiltration of metastatic cancer (breast, lung, prostate go to bones)

§  Extramedullary haematopoiesis:

·        Marrow cells outside marrow (e.g. spleen, liver, lymph nodes)

·        Common in MPD, especially myelofibrosis

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Medicine Study Notes : Haematology and Immunology : Myeloproliferative Disorders (MPD) |

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