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Chapter: Clinical Dermatology: Connective tissue disorders

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Eosinophilic fasciitis

Localized areas of skin become indurated, sometimes after an upper respiratory tract infection or prolonged severe exercise.

Eosinophilic fasciitis

Localized areas of skin become indurated, sometimes after an upper respiratory tract infection or prolonged severe exercise. Hypergammaglobulinaemia and eo-sinophilia are present and a deep skin biopsy, which includes muscle, shows that the fascia overlying the muscle is thickened. Despite its name, and despite a profound eosinophilia in the peripheral blood, the fascia is not eosinophilic or permeated by eosinophils. 

The disease responds promptly to systemic steroids; the long-term prognosis is good but disability in the short term can be severe.

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