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Chapter: Clinical Dermatology: Connective tissue disorders

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CREST syndrome

This is a variant of systemic sclerosis with a relatively good prognosis associated often with serum anti-bodies to nuclear centromeres.

CREST syndrome

This is a variant of systemic sclerosis with a relatively good prognosis associated often with serum anti-bodies to nuclear centromeres. The mnemonic stands for Calcinosis, Raynaud’s phenomenon, oEsophageal dysmotility, Sclerodactyly and Telangiectasia. Telan-giectasia is peri-ungual on the fingers and flat, mat-like or rectangular on the face. Many patients with this syndrome develop a diffuse progressive systemic sclerosis after months or years.

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