Rhinoviruses are known as the common cold viruses. They represent the major causes of mild URI syndromes in all age groups, especially older children and adults. Lower respiratory tract disease caused by rhinoviruses is uncommon. The usual incubation period is 2 to 3 days, and acute symptoms commonly last 3 to 7 days. Interestingly, mucosal cell damage is minimal during the illness. Data suggest that activation and an increase in kinins, particularly bradykinin, may have a major role in the pathogenesis of increased secretions, vasodilation, and sore throat. Rhinovirus infections may be seen at any time of the year. Epidemic peaks tend to occur in the early fall or spring months.