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Chapter: Medicine and surgery: Haematology and clinical Immunology

Megaloblastic anaemia - Macrocytic anaemia

Megaloblastic anaemia is characterised by the presence in the bone marrow of megaloblasts and macrocytic red blood cells. - Definition, Incidence, Aetiology, Pathophysiology, Clinical features, Complications, Investigations, Management, Prognosis.

Megaloblastic anaemia

 

Definition

 

Megaloblastic anaemia is characterised by the presence in the bone marrow of megaloblasts and macrocytic red blood cells.

 

Aetiology

 

The causes of megaloblastic are shown in Fig. 12.3.

 



Pathophysiology

 

Defective DNA synthesis (see Fig. 12.4) causes delayed nuclear maturation in red cell precursors (erythroblasts), which are enlarged (megaloblasts) and develop into enlarged red blood cells (macrocytes). There is also abnormal neutrophil development.

 

Clinical features

 

Symptoms and signs of anaemia.


Investigations


Full blood count demonstrates anaemia with macrocytosis (raised MCV). Blood film also reveals neutrophils with a hypersegmented nucleus. Serum vitamin B12 and red cell folate levels should be measured. For further investigations and management see below.

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Medicine and surgery: Haematology and clinical Immunology : Megaloblastic anaemia - Macrocytic anaemia |


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