Chapter: Medicine and surgery: Haematology and clinical Immunology

Haemoglobinopathies

Haemoglobinopathies are abnormalities in the normal structure of the haemoglobin molecule.

Haemoglobinopathies

 

Haemoglobinopathies are abnormalities in the normal structure of the haemoglobin molecule. Normal haemoglobin is made up of four polypeptide chains each containing a haem group. HbA is the main adult form comprising two α chains and two β chains. Adults also have a minor haemoglobin HbA2, which makes up around 2% of the circulating haemoglobin and consists of two α chains and two δ chains. Abnormal haemoglobins result from:

 

·        Abnormal globin chain production such as thalassaemia.

 

·        Abnormal structure of the globin chain in sickle cell disease.

 


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Medicine and surgery: Haematology and clinical Immunology : Haemoglobinopathies |


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