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Chapter: Modern Medical Toxicology: Neurotoxic Poisons: Anaesthetics and Muscle Relaxants

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Fentanyl and Droperidol - Intravenous Anaesthetics

When fentanyl citrate (an opiate) is combined with droperidol (a neuroleptic), a state of neuroleptanalgesia is produced during which a number of diagnostic or minor surgical procedures can be performed.

Fentanyl and Droperidol

When fentanyl citrate (an opiate) is combined with droperidol (a neuroleptic), a state of neuroleptanalgesia is produced during which a number of diagnostic or minor surgical procedures can be performed. A common precomposed mixture contains 0.05 mg of fentanyl and 2.5 mg of droperidol per millilitre. This is given as an IV infusion. Neuroleptanalgesia can be converted to neuroleptanaesthesia by the concurrent administration of 65% nitrous oxide in oxygen.

Adverse effects of neuroleptanalgesia include respiratory depression (which can be treated with naloxone), extrapy-ramidal reactions (which respond to atropine or benztropine), and hypotension.


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