The toxic profile of barbiturates, benzodiazepines, and opiates has been discussed elsewhere and hence will not be dealt with here.
Etomidate is a synthetic carboxylate imidazole and is a potent ultra-short acting hypnotic agent without analgesic properties. Overdose may result in prolonged unconsciousness. Etomidate inhibits adrenal steroidogenesis which may be the reason for increased mortality when it was used for prolonged sedation of critically ill patients.
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