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Chapter: Biochemistry: The Metabolism of Nitrogen

Chemotherapy and Antibiotics - Taking Advantage of the Need for Folic Acid

This importance has been exploited in human medicine.

Chemotherapy and Antibiotics—Taking Advantage of the Need for Folic Acid

We have already seen the importance of folic acid and its derivative, tetrahydrofolate, in several reactions. This importance has been exploited in human medicine. Bacteria synthesize folic acid from p-aminobutyric acid (PABA). A type of antibiotic called a sulfonamide (Figure a) works by competing with PABA in the synthesis of folic acid. 

Because folic acid is critical to the formation of purines, antagonists of folic acid metabolism are used to inhibit nucleic acid synthesis and cell growth. Rapidly dividing cells, such as those found in cancer and tumors, are more susceptible to these antagonists. Several related compounds, such as methotrexate (Figure b), are used in chemotherapy to inhibit cancer cell growth.


(a) Sulfa drugs (sulfonamides) act as antibiotics because of their similarity to p-aminobenzoic acid (PABA), a precursor of folic acid synthesis. Sulfa drugs compete with PABA and stop folic acid synthesis in bacteria. (b) Three compounds that are used for chemotherapy because they interfere with folic acid metabolism. They are almost irreversible inhibitors of dihydrofolate reductase, having a 1000-fold greater affinity than dihydrofolate.


 

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Biochemistry: The Metabolism of Nitrogen : Chemotherapy and Antibiotics - Taking Advantage of the Need for Folic Acid |


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