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Chapter: Medical Microbiology: An Introduction to Infectious Diseases: Influenza, Respiratory Syncytial Virus, Adenovirus, and Other Respiratory Viruses

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Rhinoviruses - Virology

The rhinovirus group comprises at least 115 accepted serotypes and more that are not yet classified.

RHINOVIRUSES

 

VIROLOGY

The rhinovirus group comprises at least 115 accepted serotypes and more that are not yet classified. These picornaviruses are small (20 to 30 nm), naked particles containing sin-gle-stranded, positive-sense RNA. They are distinguished from enteroviruses by their acid lability and an optimum temperature of 33 C for in vitro replication. This temperature approximates that of the nasopharynx in the human host and may be a factor in the local-ization of pathologic findings at that site. Rhinoviruses are most consistently isolated in cultures of human diploid fibroblasts. The receptor for most rhinoviruses (and some cox-sackieviruses) is glycoprotein intercellular adhesion molecule 1 (ICAM-1), a member of the immunoglobulin supergene family. ICAM-1 is best known for its role in immunologic cell adhesion; its ligand is lymphocyte function-associated antigen-1.

 

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