Lesch-Nyhan
Syndrome
A deficiency of the HGPRT enzyme is the cause of Lesch–Nyhan
syndrome, a genetic disease. The biochemical consequences include an elevated
concentration of PRPP and increased production of purines and uric acid. The
accumulation of uric acid leads to kidney stones and gout, but the most
striking clinical manifestations are neurological in nature. There is a
compulsive tendency toward self-mutilation among patients with Lesch–Nyhan
syndrome; they tend to bite off their fingertips and parts of their lips. The
development of kidney stones and gouty symptoms can be prevented by
administering allopurinol, but there is no real treatment for the
self-destructive behavior and the mental retardation and spasticity that
accompany it. The diverse manifestations of this disease show clearly that
metabolism is extremely complex and that the failure of one enzyme to function
can have consequences that reach far beyond the reaction that it catalyzes.
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