Variability of Drug Response
·
Disease, patient and doctor
specific factors leading to the prescribing decision
·
Absorption: formulation, GI
motility, polypharmacy (eg Grapefruit juice)
· Distribution (ie Vd)
· Plasma protein binding (generally not important unless highly bound and low Vd)
·
Metabolism: age, genetic factors,
enzyme induction and inhibition, first pass metabolism, dose-dependent
metabolism, active or toxic drug metabolites, bilary excretion, renal
elimination
·
Tissue Sensitivity
Related Topics
Privacy Policy, Terms and Conditions, DMCA Policy and Compliant
Copyright © 2018-2023 BrainKart.com; All Rights Reserved. Developed by Therithal info, Chennai.