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Chapter: Medicine Study Notes : Pharmacology

Variability of Drug Response - Pharmacokinetics

Disease, patient and doctor specific factors leading to the prescribing decision

Variability of Drug Response

 

·        Disease, patient and doctor specific factors leading to the prescribing decision

·        Absorption: formulation, GI motility, polypharmacy (eg Grapefruit juice)

·        Distribution (ie Vd)

·        Plasma protein binding (generally not important unless highly bound and low Vd) 

·        Metabolism: age, genetic factors, enzyme induction and inhibition, first pass metabolism, dose-dependent metabolism, active or toxic drug metabolites, bilary excretion, renal elimination

·        Tissue Sensitivity

 

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Medicine Study Notes : Pharmacology : Variability of Drug Response - Pharmacokinetics |


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